Hexavalent chromium has been presumed to be anthropogenic, simply inhaling small concentrations of it as low as 2 micro g/m3 can lead to irritation of the nasal mucosa and sneezing.
When hexavalent chromium works as a strong oxidizing agent, it can possibly be mutagenic and carcinogenic. On experimental animals It showed vigorous inducers of tumors, gene mutations, ability to induce a wide spectrum of DNA damage and chromosomal aberrations.
Continuous inhalation of hexavalent chromium compounds increases the risk of lung cancer. In 1990, The International Agency for Research on Cancer (IARC) established that there was sufficient evidence in humans for the carcinogenicity of chromium (VI) compounds.
Hexavalent chromium can also trigger immune system reaction when entering the organism. This reaction is caused by reduction of Cr (VI) to Cr (III) through a series of redox reactions. Trivalent chromium Cr (III) is then bind to proteins and creates haptens.
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ncbi.nlm.nih.gov
ncbi.nlm.nih.gov
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