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Opsoclonus myoclonus syndrome (OMS) – also known as “dancing eyes” syndrome – is a rare syndrome characterized by opsoclonus, myoclonus, and sometimes ataxia or encephalopathy
👇Read more 👀 #neurotwitter #tweetorial
Opsoclonus myoclonus syndrome (OMS) – also known as “dancing eyes” syndrome – is a rare syndrome characterized by opsoclonus, myoclonus, and sometimes ataxia or encephalopathy
👇Read more 👀 #neurotwitter #tweetorial
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Opsoclonus = irregular, spontaneous, multivectorial saccadic eye movements without an intersaccadic interval
(aka “saccadomania”, “dancing eyes”, and “ocular myoclonus”)
🔍See an example case at the end!
neuroophthalmology.ca
Opsoclonus = irregular, spontaneous, multivectorial saccadic eye movements without an intersaccadic interval
(aka “saccadomania”, “dancing eyes”, and “ocular myoclonus”)
🔍See an example case at the end!
neuroophthalmology.ca
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Opsoclonus are saccadic intrusions WITHOUT intersaccadic interval:
↔️ Ocular flutter = ONLY horizontal
↔️↕️🔁Opsoclonus = horizontal, vertical and/or torsional movements
⏸️Intersaccadic interval = macrosaccadic oscillations or square-wave jerks
collections.lib.utah.edu
Opsoclonus are saccadic intrusions WITHOUT intersaccadic interval:
↔️ Ocular flutter = ONLY horizontal
↔️↕️🔁Opsoclonus = horizontal, vertical and/or torsional movements
⏸️Intersaccadic interval = macrosaccadic oscillations or square-wave jerks
collections.lib.utah.edu
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Pathophysiology of OMS remains unknown, however is postulated to involve loss of inhibitory signals🚫🛑:
1️⃣ from Purkinje cells in the cerebellar vermis
2️⃣ or from omnipause cells which normally inhibit burst neurons responsible for generating saccades
europepmc.org
Pathophysiology of OMS remains unknown, however is postulated to involve loss of inhibitory signals🚫🛑:
1️⃣ from Purkinje cells in the cerebellar vermis
2️⃣ or from omnipause cells which normally inhibit burst neurons responsible for generating saccades
europepmc.org
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OMS can be autoimmune, parainfectious, paraneoplastic, or idiopathic. Both humoral and cell-mediated immune mechanisms are suspected
omsusa.org
OMS can be autoimmune, parainfectious, paraneoplastic, or idiopathic. Both humoral and cell-mediated immune mechanisms are suspected
omsusa.org
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OMS has been associated with a wide variety of viral or bacterial pathogens, including SARS-CoV-2 in #COVID19:
n.neurology.org
OMS has been associated with a wide variety of viral or bacterial pathogens, including SARS-CoV-2 in #COVID19:
n.neurology.org
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20-40% of OMS cases are paraneoplastic:
- 🧓 Small cell lung and breast cancers most common in adults
- 🧒🏽 Neuroblastoma most common in children
- 👩 Ovarian teratoma in women under age 30
ja.ma via @JAMANeuro
20-40% of OMS cases are paraneoplastic:
- 🧓 Small cell lung and breast cancers most common in adults
- 🧒🏽 Neuroblastoma most common in children
- 👩 Ovarian teratoma in women under age 30
ja.ma via @JAMANeuro
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⁉️ Pop Quiz ⁉️
When sending paraneoplastic antibodies in OMS, what is typically found?
⁉️ Pop Quiz ⁉️
When sending paraneoplastic antibodies in OMS, what is typically found?
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🧪Specific autoantibodies are often NOT identified in OMS❌
the EXCEPTION is some cases with anti-Ri (antineuronal nuclear autoantibody type 2/ANNA-2) associated with breast cancer
🧪Specific autoantibodies are often NOT identified in OMS❌
the EXCEPTION is some cases with anti-Ri (antineuronal nuclear autoantibody type 2/ANNA-2) associated with breast cancer
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Management of OMS:
- 🎗️ Early detection and treatment of underlying cancer if paraneoplastic
- 💉 IV corticosteroids, plasma exchange, IVIg, cyclophosphamide or rituximab
- 💊 Symptomatic improvement with clonazepam and topiramate
Management of OMS:
- 🎗️ Early detection and treatment of underlying cancer if paraneoplastic
- 💉 IV corticosteroids, plasma exchange, IVIg, cyclophosphamide or rituximab
- 💊 Symptomatic improvement with clonazepam and topiramate
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In existing literature, paraneoplastic OMS precedes identification of neoplasm
@ubcneuro's @aajonesy & @tychicuschen report a unique case of delayed OMS after ovarian teratoma resection in @journalneurooph - check it it out! 👇
journals.lww.com
In existing literature, paraneoplastic OMS precedes identification of neoplasm
@ubcneuro's @aajonesy & @tychicuschen report a unique case of delayed OMS after ovarian teratoma resection in @journalneurooph - check it it out! 👇
journals.lww.com
Delayed Opsoclonus-Myoclonus Syndrome After Ovarian Teratoma Resection #neurotwitter
Full Article: journals.lww.com
Full Article: journals.lww.com
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