I've noticed that taking large oral doses of pregnenolone (1 gram or even more) have profound anti inflammatory effects on my gut, and i think this is a key reason why:
pregnenolone inhibits CRH release from the hypothalamus, which is one of the primary promoters of intestinal…
pregnenolone inhibits CRH release from the hypothalamus, which is one of the primary promoters of intestinal…
"Preclinical studies show that activation of the CRF1 receptor by exogenous CRF or stress recapitulates many functional symptoms of IBS diarrhea-predominant patients as related to anxiogenic/hypervigilant behavior, autonomic nervous system alterations, induction of diarrhea,…
and CRH drives serotonin production
Psychological stress and corticotropin-releasing hormone increase intestinal permeability in humans by a mast cell-dependent mechanism gut.bmj.com
gut symptoms via CRH activity manifest due in part to serotonin
"5-HT3 receptors are involved in both abnormal colonic water transport and defecation induced by CRF, and that the inhibitory effects of 5-HT3 receptor antagonists on CRF-induced abnormal defecation partly result…
"5-HT3 receptors are involved in both abnormal colonic water transport and defecation induced by CRF, and that the inhibitory effects of 5-HT3 receptor antagonists on CRF-induced abnormal defecation partly result…
Finasteride blocks conversion of allopregnanolone synthesis, and induces gut inflammation due to the lack of this important metabolite of pregnenolone.
"the decrease in [allopregnanolone] levels correlates with an increase in IL-1β and TNF-α, serotonin and a decrease in…
"the decrease in [allopregnanolone] levels correlates with an increase in IL-1β and TNF-α, serotonin and a decrease in…
TLRs are critical sensors of bacteria in the gut, and drive serotonin production and other inflammation
"Of note, the expression levels of the TLR2 and TLR4 is increased in the inflammatory cells of the lamina propria and specifically in the intestinal macrophages during…
"Of note, the expression levels of the TLR2 and TLR4 is increased in the inflammatory cells of the lamina propria and specifically in the intestinal macrophages during…
TLRs in the gut increase serotonin production.
Anti bacterial (against endotoxin producing bacteria) effects of pregnenolone ! journaljpri.com
This paper was published out of Bulgaria
@brainenergy4me this, AlloP, serotonin antagonists, DHT, lidocaine have been very potent intestinal anti inflammatories in my experience. Going to experiment w BPC 157 soon too
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