#MayoIDQ An 80M, RHD, remote prosthetic AVR.
CC: dyspnea / CHF.
Now, F/C.
PE: SEM / click. JVD. LE edema.
WBC 16 Cr 1.5
BC: Streptococcus lutetiensis.
TEE: โrockingโ AV prosthesis.
You start Ceftriaxone, request cardiac surgery eval, and work up for what associated disease?
CC: dyspnea / CHF.
Now, F/C.
PE: SEM / click. JVD. LE edema.
WBC 16 Cr 1.5
BC: Streptococcus lutetiensis.
TEE: โrockingโ AV prosthesis.
You start Ceftriaxone, request cardiac surgery eval, and work up for what associated disease?
3/
Case diagnosis:
Streptococcus lutetiensis prosthetic aortic valve endocarditis
MCQ answer: colon cancer
S. lutetiensis is a member of โS bovis/equinusโ group
Biotype 1
S. gallolyticus
Biotype II
S. infantarius
S. lutetiensis
S. pasteurianus
ncbi.nlm.nih.gov
Case diagnosis:
Streptococcus lutetiensis prosthetic aortic valve endocarditis
MCQ answer: colon cancer
S. lutetiensis is a member of โS bovis/equinusโ group
Biotype 1
S. gallolyticus
Biotype II
S. infantarius
S. lutetiensis
S. pasteurianus
ncbi.nlm.nih.gov
5/
S #bovis #endocarditis and #colorectalcancer
Of all Streptococcus bovis infections, โendocarditisโ has the strongest association with colorectal cancer (OR 14.54, 95% CI 5.66โ37.35)
doi.org
S #bovis #endocarditis and #colorectalcancer
Of all Streptococcus bovis infections, โendocarditisโ has the strongest association with colorectal cancer (OR 14.54, 95% CI 5.66โ37.35)
doi.org
6/
S #bovis #endocarditis
S bovis: 3.8% of IE episodes (variable on geography)
- most common biotype 1 (S. gallolyticus)
- high prevalence of colonic tumors
- no preexisting valve disease
- aortic valve most commonly affected
- usually small vegetations
doi.org
S #bovis #endocarditis
S bovis: 3.8% of IE episodes (variable on geography)
- most common biotype 1 (S. gallolyticus)
- high prevalence of colonic tumors
- no preexisting valve disease
- aortic valve most commonly affected
- usually small vegetations
doi.org
7/
Which S bovis subspecies is most commonly associated with colorectal cancer?
S. #bovis biotype I (S. gallolyticus subsp. gallolyticus) bacteremia and infective endocarditis and risk of colonic neoplasm
ncbi.nlm.nih.gov
Which S bovis subspecies is most commonly associated with colorectal cancer?
S. #bovis biotype I (S. gallolyticus subsp. gallolyticus) bacteremia and infective endocarditis and risk of colonic neoplasm
ncbi.nlm.nih.gov
8/
S. #bovis isolates over a 16-year period:
- 74% (31/42) of S. bovis biotype I (S. gallolyticus subsp. gallolyticus) isolates were associated with endocarditis and 57% (24/42) were associated with colonic tumors.
link.springer.com
S. #bovis isolates over a 16-year period:
- 74% (31/42) of S. bovis biotype I (S. gallolyticus subsp. gallolyticus) isolates were associated with endocarditis and 57% (24/42) were associated with colonic tumors.
link.springer.com
9/
Metaanalysis
S. #bovis biotype I (S. #gallolyticus subsp. gallolyticus)
- Risk for colorectal carcinoma (OR, 7.26; 95%CI, 3.94-13.36) compared with biotype II infections
- More common cause of infective endocarditis than S. bovis biotype II.
doi.org
Metaanalysis
S. #bovis biotype I (S. #gallolyticus subsp. gallolyticus)
- Risk for colorectal carcinoma (OR, 7.26; 95%CI, 3.94-13.36) compared with biotype II infections
- More common cause of infective endocarditis than S. bovis biotype II.
doi.org
/10
#Bacteremia asstd w #colorectalcancer
Study of >13K patients
B fragilis (HR = 3.85)
C septicum (HR = 17.1)
C perfringens (HR = 2.29)
G morbillorum (HR = 15.2)
F nucleatum (HR = 6.89)
Peptostreptococcus sp (HR = 3.06)
S bovis/gallolyticus (HR = 5.73)
doi.org
#Bacteremia asstd w #colorectalcancer
Study of >13K patients
B fragilis (HR = 3.85)
C septicum (HR = 17.1)
C perfringens (HR = 2.29)
G morbillorum (HR = 15.2)
F nucleatum (HR = 6.89)
Peptostreptococcus sp (HR = 3.06)
S bovis/gallolyticus (HR = 5.73)
doi.org
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