#NeudrawlogyMigraineEdition, part 3! 🤕🧠
Migraine is an inherited disorder 🧬of sensory processing with 5 defined phases.
They do not need to occur in every person or even in every attack, and they may overlap.
A 🧵! (1/5)
#NeuroTwitterNetwork #NeuroTwitter #FOAMed #MedEd
Migraine is an inherited disorder 🧬of sensory processing with 5 defined phases.
They do not need to occur in every person or even in every attack, and they may overlap.
A 🧵! (1/5)
#NeuroTwitterNetwork #NeuroTwitter #FOAMed #MedEd
1/ Migraine’s pathophysiology is very complex and involves:
- Primary neuronal dysfunction
- Cortical spreading depression of Leão (it is thought to cause both the aura and the headache)
- Activation of trigeminal afferents causing inflammation
- Primary neuronal dysfunction
- Cortical spreading depression of Leão (it is thought to cause both the aura and the headache)
- Activation of trigeminal afferents causing inflammation
2/ Migraine attacks may be caused by triggers.
Common studied triggers are alcohol 🍻, sleep disturbances 😴 (either sleeping late, not sleeping or sleeping too much), some types of food 🍽, hormones✨, and emotional stress🤯.
Common studied triggers are alcohol 🍻, sleep disturbances 😴 (either sleeping late, not sleeping or sleeping too much), some types of food 🍽, hormones✨, and emotional stress🤯.
3/ But… each person is different, and, again, migraine is a complex disease. Many other triggers are not listed above and not yet studied, so a careful history and a headache diary are essential steps in the treatment!
4/ This was part 3 of #NeudrawlogyMigraineEdition! Part 4 is coming soon! Thank you for reading 🥰
5/ 📚References (1/4):
- Recober A. Pathophysiology of Migraine. Continuum (Minneap Minn). 2021;27(3):586-596. doi:10.1212/CON.0000000000000983
- Silberstein SD. Migraine. Lancet. 2004;363(9406):381-391. doi:10.1016/S0140-6736(04)15440-8
- Recober A. Pathophysiology of Migraine. Continuum (Minneap Minn). 2021;27(3):586-596. doi:10.1212/CON.0000000000000983
- Silberstein SD. Migraine. Lancet. 2004;363(9406):381-391. doi:10.1016/S0140-6736(04)15440-8
6/ 📚References (2/4):
- Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition. Cephalalgia. 2018;38(1):1-211. doi:10.1177/0333102417738202
- Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition. Cephalalgia. 2018;38(1):1-211. doi:10.1177/0333102417738202
6/ 📚References (3/4):
- Charles A. The pathophysiology of migraine: implications for clinical management. Lancet Neurol. 2018;17(2):174-182. doi:10.1016/S1474-4422(17)30435-0
- Charles A. The pathophysiology of migraine: implications for clinical management. Lancet Neurol. 2018;17(2):174-182. doi:10.1016/S1474-4422(17)30435-0
6/ 📚References (4/4):
- Fraser CL, Hepschke JL, Jenkins B, Prasad S. Migraine Aura: Pathophysiology, Mimics, and Treatment Options. Semin Neurol. 2019;39(6):739-748. doi:10.1055/s-0039-1700525
- Fraser CL, Hepschke JL, Jenkins B, Prasad S. Migraine Aura: Pathophysiology, Mimics, and Treatment Options. Semin Neurol. 2019;39(6):739-748. doi:10.1055/s-0039-1700525
Loading suggestions...