Josh Trebach, MD
Josh Trebach, MD

@jtrebach

2 Tweets 8 reads Jan 29, 2022
A 22-year-old female presents to the emergency department with seizures. She keeps seizing despite receiving benzodiazepines.
Her bestie says they were foraging mushrooms and shows you THIS picture.
☠️ ☠️
What treatment is warranted?
This nasty shroom (kind of looks like a brain or scrotum) is a GYROMITRA and contains GYROMITRIN! This gets hydrolyzed to monomethylhydrazine which reacts with pyridoxine so you cannot make GABA...which makes you seize!
This person needs to receive PYRIDOXINE (Vitamin B6)!! 😱
Treatment for these mushrooms is supportive care--this means giving activated charcoal if the patient can safely take it and benzodiazepines for initial management of seizures. Pyridoxine (Vitamin B6) is recommended in doses of 70mg/kg IV (up to 5g!) for seizures. πŸ˜΅β€πŸ’«πŸ˜΅β€πŸ’«
Remember: there are old mushroom foragers and bold mushroom foragers, but there’s no old and bold mushroom foragers😳
#ToxTweets
πŸ„ also the mushroom emoji is an Amanita muscaria πŸ„
(This case above is fictional for educational purposes)

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