Mayo Clinic Infectious Diseases
Mayo Clinic Infectious Diseases

@MayoClinicINFD

5 Tweets Apr 22, 2023
Weekend Digest
Name the pathogen
Five clues
1. #Belatacept
2. #Ibrutinib
3. #Natalizumab
4. #Rituximab
5. #Ruxolitinib
2/
JC virus (#JCV)
John Cunningham virus
Human neurotropic polyomavirus that causes progressive multifocal leukoencephalopathy (#PML).
3/
#PML is a rare, fatal, demyelinating disease of the CNS
It occurs almost always in ICH including immunocompromised patient who take monoclonal antibody therapies (such as those listed in this thread) #natalizumab #rituximab #belatacept
4/
#JCV #PML
Multifocal demyelination caused by lytic infection of oligodendrocytes - myelin producing cells of CNS
Symptoms vary depending on site of infection. Demyelination can develop in any location in the white matter. It can occur in regions of brainstem, cerebellum.
/5
#PML is a rare but fatal CNS disease characterized by demylelination of the neuronal cells leading to severe neurological impairments.
Currently, there is no effective drug treatment for PML.
Reversal of immunosuppression is key to management!

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