#EULAR2022
From Bench to Bedside
Sjogren syndrome: from biopsy to lymphoma
🟢 Sjogren's has the highest risk of Lymphoma among all AIRDs
🟢The risk is not as high as earlier thought
🟢Most risk factors are predictive
🟢RF+ Bcells central to the MALT formation
From Bench to Bedside
Sjogren syndrome: from biopsy to lymphoma
🟢 Sjogren's has the highest risk of Lymphoma among all AIRDs
🟢The risk is not as high as earlier thought
🟢Most risk factors are predictive
🟢RF+ Bcells central to the MALT formation
#EULAR2022
From Bench to Bedside
Sjogren syndrome: from biopsy to lymphoma
🟢IgMRF+ is has significant role in MALT pathogenesis
🟢RF is oligoclonal ➡️ Monoclonal in B cells likely to develop lymphoma
From Bench to Bedside
Sjogren syndrome: from biopsy to lymphoma
🟢IgMRF+ is has significant role in MALT pathogenesis
🟢RF is oligoclonal ➡️ Monoclonal in B cells likely to develop lymphoma
#EULAR2022
From Bench to Bedside
Sjogren syndrome: from biopsy to lymphoma
🟢 RTX might not be sufficient for Sjogren's MALT
🟢 All Sjogren's MALT should be treated 👉🏻 don't leace it as it is 👉🏻 even if indolent 👉🏻 indicated ⬆️ DA
From Bench to Bedside
Sjogren syndrome: from biopsy to lymphoma
🟢 RTX might not be sufficient for Sjogren's MALT
🟢 All Sjogren's MALT should be treated 👉🏻 don't leace it as it is 👉🏻 even if indolent 👉🏻 indicated ⬆️ DA
#EULAR2022
From Bench to Bedside
Sjogren syndrome: from biopsy to lymphoma
🟢BAFF is an important mediator and a variant has been found to portend a high lymphoma risk
🟢 Polymorphism in A20 can also ⬆️ lymphoma risk
From Bench to Bedside
Sjogren syndrome: from biopsy to lymphoma
🟢BAFF is an important mediator and a variant has been found to portend a high lymphoma risk
🟢 Polymorphism in A20 can also ⬆️ lymphoma risk
#EULAR2022
From Bench to Bedside
Sjogren syndrome: from biopsy to lymphoma
🟢Our understanding of the pathogenesis leading to Lymphoma is improving
From Bench to Bedside
Sjogren syndrome: from biopsy to lymphoma
🟢Our understanding of the pathogenesis leading to Lymphoma is improving
#EULAR2022
From Bench to Bedside
Sjogren syndrome: from biopsy to lymphoma
🟢Risk Prediction of Lymphoma in Sjogren's
From Bench to Bedside
Sjogren syndrome: from biopsy to lymphoma
🟢Risk Prediction of Lymphoma in Sjogren's
#EULAR2022
From Bench to Bedside
Sjogren syndrome: from biopsy to lymphoma
🟢Key Messages from the 3 talks
From Bench to Bedside
Sjogren syndrome: from biopsy to lymphoma
🟢Key Messages from the 3 talks
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