#EULAR2022
Contrasts in pathomechanisms and treatment targets between adult and paediatric inflammatory myositis
πβπ¨ Awesome class on IIM pathogenesis
πβπ¨The MSA and Phenotype Slide is ππ»ππ»
Contrasts in pathomechanisms and treatment targets between adult and paediatric inflammatory myositis
πβπ¨ Awesome class on IIM pathogenesis
πβπ¨The MSA and Phenotype Slide is ππ»ππ»
#EULAR2022
Contrasts in pathomechanisms and treatment targets between adult and paediatric inflammatory myositis
πβπ¨Summary of Mechanisms
πβπ¨DM/JDMππ» CD4 and TH17 mediated
πβπ¨ Both Inflammatory and non inflammatory factors contribute
Contrasts in pathomechanisms and treatment targets between adult and paediatric inflammatory myositis
πβπ¨Summary of Mechanisms
πβπ¨DM/JDMππ» CD4 and TH17 mediated
πβπ¨ Both Inflammatory and non inflammatory factors contribute
#EULAR2022
πβπ¨ Type I,II IFN sig
ππ» DM/JDM>>ASS/PM>IBM>IMNM
ππ» Mi2/TIF/MDA5>>Jo1>>SRP/HMCGR
πβπ¨β¬οΈINF levels ππ»β¬οΈ disease activity
πβπ¨pDC and mDC mediated
πβπ¨Mediate Muscle atrophy(perifasicular) and Capillary loss
πβπ¨ Type I,II IFN sig
ππ» DM/JDM>>ASS/PM>IBM>IMNM
ππ» Mi2/TIF/MDA5>>Jo1>>SRP/HMCGR
πβπ¨β¬οΈINF levels ππ»β¬οΈ disease activity
πβπ¨pDC and mDC mediated
πβπ¨Mediate Muscle atrophy(perifasicular) and Capillary loss
#EULAR2022
Contrasts in pathomechanisms and treatment targets between adult and paediatric inflammatory myositis
πβπ¨NETs & LDGβ¬οΈ in Blood, Muscle, Lung & Skin
πβπ¨MDA5 β¬οΈNETs>>MJ,TIF,Jo1
Contrasts in pathomechanisms and treatment targets between adult and paediatric inflammatory myositis
πβπ¨NETs & LDGβ¬οΈ in Blood, Muscle, Lung & Skin
πβπ¨MDA5 β¬οΈNETs>>MJ,TIF,Jo1
#EULAR2022
πβπ¨ Vasculopathy JDM>>>DM
πβπ¨ Muscle damage in IIM us Multifactorial
πβπ¨ DM ππ» β¬οΈINF, TNF, NF-KB
πβπ¨IMNMππ» β¬οΈAPR and β¬οΈ Lymphocyte response
πβπ¨ASSππ» β¬οΈAPR, RNA binding β¬οΈMuscle func, ubiquitination
πβπ¨ Vasculopathy JDM>>>DM
πβπ¨ Muscle damage in IIM us Multifactorial
πβπ¨ DM ππ» β¬οΈINF, TNF, NF-KB
πβπ¨IMNMππ» β¬οΈAPR and β¬οΈ Lymphocyte response
πβπ¨ASSππ» β¬οΈAPR, RNA binding β¬οΈMuscle func, ubiquitination
#EULAR2022
πβπ¨ Calcinosis JDM>>DM
πβπ¨ CD3+ T Cells and Macrophages have a role
πβπ¨ NETs engulf Ca crystals and Ca crystals cause NETOSIS
πβπ¨Mitochondrial calcification
πβπ¨ β¬οΈ SIBLING protein expression
πβπ¨ Calcinosis JDM>>DM
πβπ¨ CD3+ T Cells and Macrophages have a role
πβπ¨ NETs engulf Ca crystals and Ca crystals cause NETOSIS
πβπ¨Mitochondrial calcification
πβπ¨ β¬οΈ SIBLING protein expression
#EULAR2022
Contrasts in pathomechanisms and treatment targets between adult and paediatric inflammatory myositis
Summary Slides
Contrasts in pathomechanisms and treatment targets between adult and paediatric inflammatory myositis
Summary Slides
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