EnvisionRheumat
EnvisionRheumat

@ERheumat

6 Tweets Jun 06, 2022
#EULAR2022
What is New (WIN)
Osteoarthritis โ€“ evolving treatments
This talk is a must-watch on-demand - highly recommended
๐Ÿ—Proposed NICE-UK guidelines for
#EULAR2022
๐Ÿ—Most trials have tried correcting catabolic pathway
๐Ÿ— Most trials in OA have failed
๐Ÿ—Cartilage though sparsely cellular/vascular exquisitely sensitive to injury
๐Ÿ— Max polymorphism in OA is found in the Anabolic pathway
#EULAR2022
What is New (WIN)
Osteoarthritis โ€“ evolving treatments
๐Ÿ—Shear stress leads to damage while compression leads to regeneration
๐Ÿ—Has been utilized in Joint distraction showing good results
#EULAR2022
What is New (WIN)
Osteoarthritis โ€“ evolving treatments
๐Ÿ—Pain might not be the perfect outcome in OA trials
๐Ÿ—Sprifermin looks promising ๐Ÿ‘‰๐Ÿป effect was more pronounced in patients with progressive disease
๐Ÿ— newer drugs on Horizon
#EULAR2022
What is New (WIN)
Osteoarthritis โ€“ evolving treatments
๐Ÿ— The right subgroup shows the right results
๐Ÿ— CANTOS showed patients on IL1i required lesser joint replacement
#EULAR2022
What is New (WIN)
Osteoarthritis โ€“ evolving treatments
the future looks brighter than bleeker for OA patients

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