Exposure to endocrine-disrupting chemicals (EDC) such as BPA, pesticides, drugs & phthalates have epigenetic effects that can be long lasting.
Itβs commonly known that EDCβs disrupt hormones, but Iβd like to list some of the detrimental epigenetic effects rq
Itβs commonly known that EDCβs disrupt hormones, but Iβd like to list some of the detrimental epigenetic effects rq
Exposure to BPA decreases methylation from DHMT1 by increasing the expression of miRNA-29.
BPA also deregulates the enzymes responsible for DNA de-methylation such as TET.
These in combination can halt the important use of methylation to regulate the epigenome.
BPA also deregulates the enzymes responsible for DNA de-methylation such as TET.
These in combination can halt the important use of methylation to regulate the epigenome.
EDC exposure also affects histone modifying enzymes which control acetylation. The activity of KAT2A & HDAC1, 2 & 3 is significantly decreased resulting in reduced expression of genes.
BPA specifically results in decreased expression of insulin like growth factor binding protein 5 (IGFBP5) as a downstream effect of the phosphorylation of EZH2; this series of events is closely connected to breast cancer.
EDCs also have the power to disrupt the entire methyl cycle; SAM (the universal methyl donor)(very important) is synthesized from methionine andenosyltransferase (MAT). EDCs target MAT & prevent the synthesis of SAM
When I discuss epigenetics on here should I break things down & explain them or keep things at an advanced level
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