Weekend Digest
Name the Pathogen
Five Clues
1. NOT a virus, fungus, bacteria or parasite
2. Traumatic inoculation
3. #Morula with daisy pattern
4. Olecranon #bursitis
5. Rx not well defined; #Amphotericin B
Name the Pathogen
Five Clues
1. NOT a virus, fungus, bacteria or parasite
2. Traumatic inoculation
3. #Morula with daisy pattern
4. Olecranon #bursitis
5. Rx not well defined; #Amphotericin B
2/
#Prototheca
1. Unicellular algae
2. Transmission (traumatic inoculation)
3. Skin/bursitis (indolent/chronic); disseminated βalgaemiaβ in ICH
4. Dx: sporangia w endospores in daisy-like pattern and morula-like septation
5. Rx: amphotericin B / azole
doi.org
#Prototheca
1. Unicellular algae
2. Transmission (traumatic inoculation)
3. Skin/bursitis (indolent/chronic); disseminated βalgaemiaβ in ICH
4. Dx: sporangia w endospores in daisy-like pattern and morula-like septation
5. Rx: amphotericin B / azole
doi.org
3/
#Prototheca - spherical unicellular algae
- Do NOT possess glucosamine, a specific fungal cell wall
- Do NOT possess muramic acid, a specific bacterial cell component
- Unlike other algae - Prototheca lacks chloroplasts
ncbi.nlm.nih.gov
#Prototheca - spherical unicellular algae
- Do NOT possess glucosamine, a specific fungal cell wall
- Do NOT possess muramic acid, a specific bacterial cell component
- Unlike other algae - Prototheca lacks chloroplasts
ncbi.nlm.nih.gov
4/
#Protothecosis: Clinical syndromes
Most infections - traumatic inoculation into subcutaneous tissues β>
Olecranon bursitis and cutaneous infections in immunocompetent host
Disseminate w/ visceral involvement in ICH
cmr.asm.org
#Protothecosis: Clinical syndromes
Most infections - traumatic inoculation into subcutaneous tissues β>
Olecranon bursitis and cutaneous infections in immunocompetent host
Disseminate w/ visceral involvement in ICH
cmr.asm.org
/5
#Protothecosis #IDDailyPearl
Things to Know: Treatment
Treatment involves medical and surgical approaches
Antifungals: ketoconazole, itraconazole, fluconazole, voriconazole, amphotericin B
Amphotericin B - best activity against Prototheca spp.
ncbi.nlm.nih.gov
#Protothecosis #IDDailyPearl
Things to Know: Treatment
Treatment involves medical and surgical approaches
Antifungals: ketoconazole, itraconazole, fluconazole, voriconazole, amphotericin B
Amphotericin B - best activity against Prototheca spp.
ncbi.nlm.nih.gov
Loading suggestions...