The lipids are powerful allergens.
ncbi.nlm.nih.gov
ncbi.nlm.nih.gov
Pseudouridylated nucleic acids resist nuclease breakdown.
frontiersin.org
frontiersin.org
They may also inhibit TLR 7/8.
medrxiv.org
medrxiv.org
Not to mention, they may trigger stop codon readthrough.
ncbi.nlm.nih.gov
ncbi.nlm.nih.gov
There may be consequences for innate immune function.
sciencedirect.com
sciencedirect.com
S is seriously toxic.
pubmed.ncbi.nlm.nih.gov
pubmed.ncbi.nlm.nih.gov
It may interact with endothelial cells.
ncbi.nlm.nih.gov
ncbi.nlm.nih.gov
It may also damage precursor cells in bone marrow.
nature.com
nature.com
It is highly inflammatory and has a SAg region.
pnas.org
pnas.org
S is also amyloidogenic. When broken down by neutrophil elastase, it makes a bunch of fragments that each act as the nuclei for amyloid fibrils.
ncbi.nlm.nih.gov
ncbi.nlm.nih.gov
It has close sequence homology with many human protein motifs, which may result in autoimmunity.
nature.com
nature.com
It may cause prion disease.
canadahealthalliance.org
canadahealthalliance.org
Healthy cells expressing S will invariably be destroyed by the immune system.
onlinelibrary.wiley.com
onlinelibrary.wiley.com
It was shown to cause myopericarditis in mouse models.
ncbi.nlm.nih.gov
ncbi.nlm.nih.gov
The risk is cumulative and increases with further doses.
nature.com
nature.com
It's not a mystery. We have many, many plausible mechanisms of injury and reams of scientific research to back it up.
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