Great question here from @BowTiedFawn about the bioavailability of collagen.
Bioavailability is a paramount concern when taking supplements: is the supp getting where itβs supposed to go & doing what itβs supposed to do, or are we just wasting money?
Letβs look at collagen π§΅π
Bioavailability is a paramount concern when taking supplements: is the supp getting where itβs supposed to go & doing what itβs supposed to do, or are we just wasting money?
Letβs look at collagen π§΅π
Here is a link to a good overview of the various studies involving the bioavailability of hydrolyzed collagen.
Hydrolyzed means that the collagen has been broken down into smaller, lighter particles that are easier for the body to digest and use.
benthamopen.com
Hydrolyzed means that the collagen has been broken down into smaller, lighter particles that are easier for the body to digest and use.
benthamopen.com
Hydrolyzed collagen peptides weigh 0.3-8.0 kDa and are made by decomposing gelatin, which weighs 100 kDa, via enzymes.
The low molecular weight of hydrolyzed collagen means that it is highly digestible and easily absorbed and distributed in the body.
The low molecular weight of hydrolyzed collagen means that it is highly digestible and easily absorbed and distributed in the body.
The study authors conclude:
βSeveral experiments have shown that collagen peptides can be efficiently absorbed & distributed to the dermisβ¦ where they can stimulate the proliferation & motility of fibroblasts; induce an increase in the density & diameter of collagen fibers;
βSeveral experiments have shown that collagen peptides can be efficiently absorbed & distributed to the dermisβ¦ where they can stimulate the proliferation & motility of fibroblasts; induce an increase in the density & diameter of collagen fibers;
Increase hyaluronic acid production & activate protection against UVA radiation.β
The key here is the use of hydrolyzed peptides. Due to its higher molecular weight, it is not clear that gelatin has the same effects.
The key here is the use of hydrolyzed peptides. Due to its higher molecular weight, it is not clear that gelatin has the same effects.
Another study concludes:
βDaily ingestion of collagen hydrolysate for a long period can change compositional rate of Hyp peptides in human blood. This fact suggests that LT ingestion of collagen hydrolysate might change exo- or endo-type protease activity in the digestiveβ¦
βDaily ingestion of collagen hydrolysate for a long period can change compositional rate of Hyp peptides in human blood. This fact suggests that LT ingestion of collagen hydrolysate might change exo- or endo-type protease activity in the digestiveβ¦
tract, which may consequently promote beneficial effects.β
pubmed.ncbi.nlm.nih.gov
pubmed.ncbi.nlm.nih.gov
Finally, a third study concludes:
βWe found that not only Pro-Hyp but also other collagen-derived peptides were transported to the skin by the ingestion of HTC-col.β
pubs.acs.org
βWe found that not only Pro-Hyp but also other collagen-derived peptides were transported to the skin by the ingestion of HTC-col.β
pubs.acs.org
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