The 4 most important blood smears for medical students for the USMLE and for life
A short tweetorial = 4 blood smears
Fevers, AMS, hemolytic anemia, thrombocytopenia =
TTP = ADAMTS13 deficiency
Rx plasmapheresis
Smear with schistocytes + thrombocytopenia
A short tweetorial = 4 blood smears
Fevers, AMS, hemolytic anemia, thrombocytopenia =
TTP = ADAMTS13 deficiency
Rx plasmapheresis
Smear with schistocytes + thrombocytopenia
25 yo with bleeding, thrombocytopenia,⬇️fibrinogen = DIC
Smear with large promyelocytes with granules, blasts with Auer rods, schistocytes can be present from DIC
APL = t(15;17)
Rx ATRA
[ASH IMAGE BANK]
Smear with large promyelocytes with granules, blasts with Auer rods, schistocytes can be present from DIC
APL = t(15;17)
Rx ATRA
[ASH IMAGE BANK]
50 yo asymptomatic with neutrophilic leukocytosis, basophilia, splenomegaly
Smear with leukocytosis rare blasts, myelocytes, sets, mature PMNs, basophils. Note WBCs many different shapes and sizes unlike acute leukemia (blasts all big).
= CML = t(9;22) =BCR-ABL1
Rx imatinib
Smear with leukocytosis rare blasts, myelocytes, sets, mature PMNs, basophils. Note WBCs many different shapes and sizes unlike acute leukemia (blasts all big).
= CML = t(9;22) =BCR-ABL1
Rx imatinib
75 yo asymptomatic gets routine CBC with WBC 150,000 almost all lymphocytes
Smear with numerous small lymphocytes with condensed nucleus and smudge cells
= CLL
Rx = Observe
[ASH IMAGE BANK]
Smear with numerous small lymphocytes with condensed nucleus and smudge cells
= CLL
Rx = Observe
[ASH IMAGE BANK]
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