Ilan Schwartz MD PhD
Ilan Schwartz MD PhD

@GermHunterMD

8 Tweets Jan 23, 2023
Wow 😱🤯
NOSOCOMIAL malaria in a non-endemic country (France)
Infections in 6 hospitalized pts without travel (over 15yrs) were linked by genomics to patients concurrently admitted with imported malaria (⭐️ in fig)
Mechanism??? Implications for IP&C???
academic.oup.com
Authors exculpated transmission by mosquitoes based on the timeline:
"the maturation cycle from gametocyte ingestion in the blood meal to the infective sporozoite stage in the salivary glands of the mosquito requires about 10-20 days ... "
"...and at least 1 additional week to have clinical signs in humans after the infecting bite. Furthermore, if it is assumed that an anopheles fed on patients with imported malaria, it is unlikely that it would then bite patients with nosocomial malaria 10 days later...
since the average lifespan of a mosquito is 7 days"
They speculate that infection was due to contaminated medical supplies/equipment
Which is in keeping with other rare occurrences due to poor IP&C practices like reusing single-use vials of medications/fluids
And although the authors reviewed a 15 year period, 4/6 of the cases occurred over the span of 3 months in 2021 when hospitals were overwhelmed with COVID19 patients, and IP&C practices may have lapsed.
Sorry, correction: hospitals in France were not overwhelmed at the time (June - Sept 2021) but maybe COVID-related burnout and other human factors were involved
Two more cases of nosocomial malaria, this time from Italy, were reported.
Unfortunately no smoking gun with regards to the mechanism of transmission/source of contamination.
bmcpublichealth.biomedcentral.com

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