1/n
Here is a thread on TAKAYASU ARTERITIS , aka PULSELESS DISEASE
Takayasu Arteritis is a Granulomatous Vasculitis of medium and large Arteries that predominantly involves aorta and its major branches
#MedTwitter
@Sthanu5 @tony_breu
Here is a thread on TAKAYASU ARTERITIS , aka PULSELESS DISEASE
Takayasu Arteritis is a Granulomatous Vasculitis of medium and large Arteries that predominantly involves aorta and its major branches
#MedTwitter
@Sthanu5 @tony_breu
2/n
The history behind this disease⁉️
Credit goes to this man ➡️ Dr. Mikito Takayasu, an Ophthalmologist
#TriviaQuiz
The history behind this disease⁉️
Credit goes to this man ➡️ Dr. Mikito Takayasu, an Ophthalmologist
#TriviaQuiz
3/n
In 1905, a 22 yr 👩 came to him with blurring of vision & redness conjuctival redness
Fundus exam showed abnormality in retinal vessels, "coronary anastomosis," an AV anastomosis around optic disc
He reported it as "Case of peculiar changes in the central retinal vessels"
In 1905, a 22 yr 👩 came to him with blurring of vision & redness conjuctival redness
Fundus exam showed abnormality in retinal vessels, "coronary anastomosis," an AV anastomosis around optic disc
He reported it as "Case of peculiar changes in the central retinal vessels"
4/n
Professor of Kyushu University, Dr. Yoshiakira Ohnishi also mentioned a case resembling the ophthalmic manifestations, which was presented by Dr. Takayasu previously along with *B/L absence of radial pulse.*
Subsequently,"Takayasu disease" name was proposed in case reports
Professor of Kyushu University, Dr. Yoshiakira Ohnishi also mentioned a case resembling the ophthalmic manifestations, which was presented by Dr. Takayasu previously along with *B/L absence of radial pulse.*
Subsequently,"Takayasu disease" name was proposed in case reports
5/n
How does TA (Takayasu Arteritis) present in pediatric age group?
✳️ Early symptoms are non specific, hence easily missed
✳️ Headache and hypertension without an alternate diagnosis
✳️ Vascular complications like ischemia, raynaud's, renal failure
How does TA (Takayasu Arteritis) present in pediatric age group?
✳️ Early symptoms are non specific, hence easily missed
✳️ Headache and hypertension without an alternate diagnosis
✳️ Vascular complications like ischemia, raynaud's, renal failure
6/n
Diagnostic Criteria
Angiographic abnormalities of aorta/its branches and any 1 of the following.. (Image Ref - Nelson 21st edition
*Lab Tests are non specific. Radiographic assessment of large vessels is crucial for Diagnosis*
Diagnostic Criteria
Angiographic abnormalities of aorta/its branches and any 1 of the following.. (Image Ref - Nelson 21st edition
*Lab Tests are non specific. Radiographic assessment of large vessels is crucial for Diagnosis*
7/n
Where do you think inflammation of vessel wall in Takayasu Arteritis start?
#pathology
#MedTwitter
Where do you think inflammation of vessel wall in Takayasu Arteritis start?
#pathology
#MedTwitter
8/n
✅ Inflammation of vessel walls in TA starts in Vasa Vasorum. (Ref- Robbins Pathology Ed. 10)
Below is an image showing intimal thickening and adventitial fibrosis causing narrowing of lumen ➡️ Pulseless Disease
✅ Inflammation of vessel walls in TA starts in Vasa Vasorum. (Ref- Robbins Pathology Ed. 10)
Below is an image showing intimal thickening and adventitial fibrosis causing narrowing of lumen ➡️ Pulseless Disease
9/n
So how do you treat children with Takayasu Arteritis?
🔺 Mainstay of therapy - Glucocorticoids
🔺 For severe/Refractory disease - Cyclophosphamide
Complications of TA -
# Stroke
# MI
# Anuerysm
# Renal failure
So how do you treat children with Takayasu Arteritis?
🔺 Mainstay of therapy - Glucocorticoids
🔺 For severe/Refractory disease - Cyclophosphamide
Complications of TA -
# Stroke
# MI
# Anuerysm
# Renal failure
Loading suggestions...