8 Tweets 19 reads Nov 04, 2022
A 66-year-old woman
๐Ÿ‘‰ 7-month history of pruritic rash
๐Ÿ‘‰ had previously received a diagnosis of eczema and received treatment with topical glucocorticoids, without improvement.
๐Ÿ‘‰ also reported fatigue, shortness of breath, and muscle weakness
๐Ÿ‘‰ examination๐Ÿ‘‰ presence of hyperpigmented, erythematous papules overlying the metacarpophalangeal and interphalangeal joints of both hands,
๐Ÿ‘‰findings consistent with Gottronโ€™s papules (A);
๐Ÿ‘‰ dilated capillaries of the proximal nail folds (B);
๐Ÿ‘‰ dyschromic patches, plaques, and poikiloderma on the postr shoulders, ๐Ÿ‘‰ shawl sign (C);
๐Ÿ‘‰poikilodermatous, dyschromic changes of the lateral thighs๐Ÿ‘‰ Holster sign (D)
๐Ÿ‘‰ strength in the proximal arms and legs was 3 out of 5
Dx dermatomyositis
๐Ÿ‘‰ Given the association between dermatomyositis and certain cancers
๐Ÿ‘‰ evaluated for underlying cancer
๐Ÿ‘‰ results of the evaluation were negative
๐Ÿ‘‰depending on dermatologic skin type, the rash can have varied presentations
๐Ÿ‘‰ hyperpigmentation and dyschromia or marked erythema with violaceous changes
๐Ÿ‘‰ 3-month course of mycophenolate mofetil, intravenous immune globulin, and prednisone was initiated,
๐Ÿ‘‰ the glucocorticoids were tapered during this time
๐Ÿ‘‰ resolution of the dyspnea, weakness, and cutaneous findings.
Dermatomyositis
nejm.org

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