Pankti Mehta
Pankti Mehta

@PanktiMehta24

9 Tweets Nov 06, 2022
The prevalence of #rheumatoidarthritis ๐ŸŒ ~1%
๐Ÿ™€ So ~14 million suffer from RA!
So we ๐Ÿ‘ฉโ€โš•๏ธ have to deal with special situations while managing this fairly common disease!
#MedTwitter #MedEd #rheumatology #RheumTwitter
@MedTweetorials @nihardesai7
(1/9)
Let's begin with one of the most beautiful miracles of life โ˜บ๏ธ
#pregnancy in #rheumatoidarthritis
(2/9)
๐Ÿค”Is it safe to conceive for a patient with RA? ๐Ÿคฐ
๐Ÿ‘‰Overall it is safe โ˜‘๏ธโ˜‘๏ธโ˜‘๏ธ
๐Ÿ‘‰But a mild risk of hypertensive disorders, IUGR and need for caesarian section +!
(3/9)
๐Ÿค” What happens to arthritis during pregnancy?
๐Ÿ˜ฃ 10-15%
๐Ÿ˜ 48-60%
๐Ÿ˜• 25-40%
#MedTwitter #MedEd
(4/9)
๐ŸคทWhat to do about the ๐Ÿ’Š?
๐ŸšซMethotrexate 1-3months prior
๐ŸšซLeflunomide, check levels sos cholestyramine washout
๐ŸšซTNFis, NSAIDs in the 3rd trimester (except certolizumab)
๐ŸšซRituximab,TCZ at conception
โœ…Sulfasalazine
โœ…Hydroxychloroquine
โœ…AZA
๐Ÿšฅ Steorids โœ… if <20mg
(5/9)
What about lactation??? ๐Ÿผ๐Ÿ‘จโ€๐Ÿผ
All safe except
๐Ÿšซ Methotrexate
๐Ÿšซ Leflunomide
Amongst NSAIDS, ibuprofen is preferred!
#MedTwitter
(6/9)
โ™‚๏ธHey we forgot about men with RA trying to father a child!
โœ… Hydroxychloroquine
โœ… AZA
โœ… TNFis
โœ… Rituximab
โœ… Methotrexate
โœ… Leflunomide
? JAKibs and Abatacept
rheumatology.org
#MedTwitter
(7/9)
Few more takeaways from ๐Ÿ‡ฌ๐Ÿ‡ง 2022 guidelines
doi.org
๐Ÿ”ธ๐Ÿšซsulfasalazine in males if conception delayed by 12 months
๐Ÿ”ธvaccination schedule of the infant needs to modified if TNFis continued during ๐Ÿคฐ( inflix, adali, etanercept)
Stop JAKibs >2 weeks priorโ™€๏ธ
(8/9)
What happens to the disease activity post pregnancy?๐Ÿผ๐Ÿ‘จโ€๐Ÿผ
๐Ÿ˜ฃ๐Ÿ˜ฃ๐Ÿ˜ฃ 39-50% flare withing 6 months postpartum!
So overall
๐Ÿ”ธPregnancy is safe ๐Ÿคฐโ˜บ๏ธ
๐Ÿ”ธ๐Ÿ’Š Modifications are needed
๐Ÿ”ธ Regular follow-up is a must โš•๏ธ
#MedTwitter #RheumTwitter
(9/9)

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