A reminder #ASH22
Uncontrolled smoldering myeloma trials are unethical
1
They don't answer a useful clinical question
100% test drugs already given in Myeloma
Of course they will be 'safe' in a pre malignant state
2
They can't tell you if OS or HRQoL is better with Tx
๐งต
Uncontrolled smoldering myeloma trials are unethical
1
They don't answer a useful clinical question
100% test drugs already given in Myeloma
Of course they will be 'safe' in a pre malignant state
2
They can't tell you if OS or HRQoL is better with Tx
๐งต
Early vs treating at progression
The Spanish study was not powered for OS, and positive OS results are likely untrue. Not to mention no PET, and unbelievably bad treatment on progression
ECOG study has not shown OS or HRQoL benefit
Doesn't tell us whether prog was irreversible
The Spanish study was not powered for OS, and positive OS results are likely untrue. Not to mention no PET, and unbelievably bad treatment on progression
ECOG study has not shown OS or HRQoL benefit
Doesn't tell us whether prog was irreversible
Uncontrolled trials cannot answer a meaningful question, and trials that cannot answer a meaningful question squander patients are are unethical
We detail that here
#ASH22
pubmed.ncbi.nlm.nih.gov
We detail that here
#ASH22
pubmed.ncbi.nlm.nih.gov
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