Next up at the Belgian Society of Nephrology. Ian MacDougall talking iron.
Patients with CKD have decreased intake and increased iron loss.
Dialysis patient red cell lifespan is 60 rather than 120 days. But iron is reprocessed. This is not a source of iron loss. Non-CKD patient lose 1 mg of iron a day.
Elevated hepcidin shuts down this recirculating. Elevated IL-6 in CKD drives the high hepcidin levels.
Hemodialysis patient absorb almost zero iron from the gut. IV iron is mandatory.
Two important studies of oral vs IV iron in non-dialysis CKD. Find-CKD and Revoke.
In REVOKE he is concerned about 5000 screened for 100 to complete
Iron was safe in REVOKE
Highlights Belgian participation in FIND-CKD
Oral iron worked in non dialysis CKD.
MacDougall calls me out as the sole Yank in the room. Representing the entire USA at Belgian Society of Nephrology.
The concern about is iron in a slide (especially in lab animals)
Associations in adopts And USRDS is damning
PIVOTAL trial exonerated iron. Not only no signal for harm but a benefit from aggressive iron depletion.
No infection signal
Which iron prep?
Loading suggestions...