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As you saw in the (sanitised) image above, humans seem to have a different expression of something. But of what? and what does it had to do with #Pfizer/#BioNTech experimental gene therapy, known as #BNT162b2/#Comirnaty/#tozinameran?
Let's find out.
#TheRats
As you saw in the (sanitised) image above, humans seem to have a different expression of something. But of what? and what does it had to do with #Pfizer/#BioNTech experimental gene therapy, known as #BNT162b2/#Comirnaty/#tozinameran?
Let's find out.
#TheRats
6/
#Pfizer/#BionTech didn't perform ecotoxicity / environmental risk assessment. The 2019 version of the NIH Guidelines on Research Involving (m)RNA Molecules lacked an appendix w/specific guidance on it, and it was a guidance, NOT a requirement.
advarra.com
#TheRats
#Pfizer/#BionTech didn't perform ecotoxicity / environmental risk assessment. The 2019 version of the NIH Guidelines on Research Involving (m)RNA Molecules lacked an appendix w/specific guidance on it, and it was a guidance, NOT a requirement.
advarra.com
#TheRats
8/
According to this guidance, the testing of #Prizer/#BionTech "vaccine", a product that had no prior nonclinical and clinical experience, was "expected to be more extensive than for those vaccines previously licensed and used in humans".
web.archive.org
#TheRats
According to this guidance, the testing of #Prizer/#BionTech "vaccine", a product that had no prior nonclinical and clinical experience, was "expected to be more extensive than for those vaccines previously licensed and used in humans".
web.archive.org
#TheRats
18/
This Kd value depend on HOW #Pfizer/#BioNTech measured it! It is dependant on the concentration regime under which the reported Kd values were measured, and the time they waited to measure it!
They can cheat by using a "Titration regime"!
elifesciences.org
#TheRats
This Kd value depend on HOW #Pfizer/#BioNTech measured it! It is dependant on the concentration regime under which the reported Kd values were measured, and the time they waited to measure it!
They can cheat by using a "Titration regime"!
elifesciences.org
#TheRats
21/
It's important because immune response (IgG) was much more likely to bind to the RBD of a #SARSCoV2 than the spike itself, which CREATES NEUTRALIZATION ESCAPE VARIENTS, which #Pfizer/#BioNTech KNEW SINCE 2014! The S2 was MUCH better choice!
ncbi.nlm.nih.gov
#TheRats
It's important because immune response (IgG) was much more likely to bind to the RBD of a #SARSCoV2 than the spike itself, which CREATES NEUTRALIZATION ESCAPE VARIENTS, which #Pfizer/#BioNTech KNEW SINCE 2014! The S2 was MUCH better choice!
ncbi.nlm.nih.gov
#TheRats
24/
A small note - I will not cover #Pfizer/#BioNTech vitro experiment. I also decided to exclude the topic of the lipid nanoparticle because it is too technical for most people. Perhaps in another thread on the topic.
Why? Becauseβ¦
#TheRats
youtube.com
A small note - I will not cover #Pfizer/#BioNTech vitro experiment. I also decided to exclude the topic of the lipid nanoparticle because it is too technical for most people. Perhaps in another thread on the topic.
Why? Becauseβ¦
#TheRats
youtube.com
25/
THIS IS NOT THE END OF THIS THREAD!
In the next part I will go over the rest of the animal experiments. I know it's long, but you'll understand why really soon! I promise!
Don't forget to use the "Show replies" if the thread seems to have stopped abruptly π
#TheRats
THIS IS NOT THE END OF THIS THREAD!
In the next part I will go over the rest of the animal experiments. I know it's long, but you'll understand why really soon! I promise!
Don't forget to use the "Show replies" if the thread seems to have stopped abruptly π
#TheRats
28/
#Pfizer/#BioNTech's "SARS-CoV-2 convalescent human sera (serum)" is SARS-CoV-2 neutralizing antibodies in sera from recovered COVID-19 patients.
Here is article that describes the experiment, and below you can read what they got.
#Sec7" target="_blank" rel="noopener" onclick="event.stopPropagation()">nature.com
#TheRats
#Pfizer/#BioNTech's "SARS-CoV-2 convalescent human sera (serum)" is SARS-CoV-2 neutralizing antibodies in sera from recovered COVID-19 patients.
Here is article that describes the experiment, and below you can read what they got.
#Sec7" target="_blank" rel="noopener" onclick="event.stopPropagation()">nature.com
#TheRats
30/
Not. Having too many antibodies in your body is not a good thing, and #Pfizer/#BioNTech knew about it, as well as everyone who knows anything about the immune system.
A value of 600 seems normal based on the following research:
journals.asm.org
#TheRats
Not. Having too many antibodies in your body is not a good thing, and #Pfizer/#BioNTech knew about it, as well as everyone who knows anything about the immune system.
A value of 600 seems normal based on the following research:
journals.asm.org
#TheRats
37/
The repeat dosage toxicity was done using two formulas of #Pfizer/#BioNTech "vaccine", V8 and V9. V9 was the one approved, yet they still used the data from V8 as part of their submission. The difference? Codon Optimization (see #COptiGate).
No one cared.
#TheRats
The repeat dosage toxicity was done using two formulas of #Pfizer/#BioNTech "vaccine", V8 and V9. V9 was the one approved, yet they still used the data from V8 as part of their submission. The difference? Codon Optimization (see #COptiGate).
No one cared.
#TheRats
38/
The redacted "INVESTIGATORβS BROCHURE" pages 37 to 50 gave more details about experiments 38166 & 20GR142:
tga.gov.au
Sasha Latypova's review on the topic (which I only discovered after finishing my analysis) is here:
home.solari.com
#TheRats
The redacted "INVESTIGATORβS BROCHURE" pages 37 to 50 gave more details about experiments 38166 & 20GR142:
tga.gov.au
Sasha Latypova's review on the topic (which I only discovered after finishing my analysis) is here:
home.solari.com
#TheRats
40/
AS you can see below, the still-slightly-sanitised image describe differences between human, mice, and rats. It is obvious just by looking at the image that mice has much less expression and rats seems to barely have any expression of something.
But what is it?
#TheRats
AS you can see below, the still-slightly-sanitised image describe differences between human, mice, and rats. It is obvious just by looking at the image that mice has much less expression and rats seems to barely have any expression of something.
But what is it?
#TheRats
42/
Scientists who studied SARS-CoV, including ones in #Pfizer/#BioNTech, knew that "Infection with S protein-pseudotyped retrovirus (W/SARS-CoV S protein) is less efficient in cells expressing rodent ACE2 than in those expressing human ACE2".
ncbi.nlm.nih.gov
#TheRats
Scientists who studied SARS-CoV, including ones in #Pfizer/#BioNTech, knew that "Infection with S protein-pseudotyped retrovirus (W/SARS-CoV S protein) is less efficient in cells expressing rodent ACE2 than in those expressing human ACE2".
ncbi.nlm.nih.gov
#TheRats
44/
I believe #Pfizer/#BioNTech used rhesus (rh) macaques because they "do not usually develop SARS after SARS-CoV infectionβ¦Rh-ACE2β¦is more polymorphic than hu-ACE2β¦and did not support viral entry effectively".
It was known since 2008.
#TheRats
ncbi.nlm.nih.gov
I believe #Pfizer/#BioNTech used rhesus (rh) macaques because they "do not usually develop SARS after SARS-CoV infectionβ¦Rh-ACE2β¦is more polymorphic than hu-ACE2β¦and did not support viral entry effectively".
It was known since 2008.
#TheRats
ncbi.nlm.nih.gov
45/
#Pfizer/#BioNTech also used Vero E6 cells to make the #SARSCoV2 inoculum for the monkeys, but "compared to SARS-CoV, SARS-CoV-2 generated higher levels of intracellular viral RNA, but strikingly ABOUT 50-FOLD LESS INFECTIOUS VIRAL PROGENY".
#TheRats
microbiologyresearch.org
#Pfizer/#BioNTech also used Vero E6 cells to make the #SARSCoV2 inoculum for the monkeys, but "compared to SARS-CoV, SARS-CoV-2 generated higher levels of intracellular viral RNA, but strikingly ABOUT 50-FOLD LESS INFECTIOUS VIRAL PROGENY".
#TheRats
microbiologyresearch.org
47/
3) The spike proteins barely binds to rats ACE2 receptors; the vast majority of them do not penetrate organs with ACE2 receptors (e.g. heart).
4) The rats body starts to create huge amount of spike-RBD-binding IgG, trying to get rid of the free spikes.
#TheRats
3) The spike proteins barely binds to rats ACE2 receptors; the vast majority of them do not penetrate organs with ACE2 receptors (e.g. heart).
4) The rats body starts to create huge amount of spike-RBD-binding IgG, trying to get rid of the free spikes.
#TheRats
48/
5) The "lonely" spike proteins (who don't have an ACE2 to bind to) can be problematic floating around (especially when it S2P structure is unstable, leading to disease prions), but it is better than the damage the spike is doing to the cells (e.g. mitochondria).
#TheRats
5) The "lonely" spike proteins (who don't have an ACE2 to bind to) can be problematic floating around (especially when it S2P structure is unstable, leading to disease prions), but it is better than the damage the spike is doing to the cells (e.g. mitochondria).
#TheRats
53/
The impact of such flooding (for the rat) is more activation of its immune system without a massive damage due to the spike->ACE2 "underperformance". The higher dosage that might work for the rat, but for someone else (human) it would overflow the ACE2 in their body.
#TheRats
The impact of such flooding (for the rat) is more activation of its immune system without a massive damage due to the spike->ACE2 "underperformance". The higher dosage that might work for the rat, but for someone else (human) it would overflow the ACE2 in their body.
#TheRats
54/
There has been a lot of research & development of mice with a human ACE2. Here is one example. But #Pfizer/#BioNTech didn't had the time to get such animals, so, like with Codon Optimization (#COptiGate) they just didn't acknowledge it.
#TheRats
genengnews.com
There has been a lot of research & development of mice with a human ACE2. Here is one example. But #Pfizer/#BioNTech didn't had the time to get such animals, so, like with Codon Optimization (#COptiGate) they just didn't acknowledge it.
#TheRats
genengnews.com
61/
I reached out to few experts. The minute they confirm my understanding (or what happened), I will share it with you.
The reason I decided to focus on this rather than just write about the regulators is because there is a HUGE importance to these animal experiments.
#TheRats
I reached out to few experts. The minute they confirm my understanding (or what happened), I will share it with you.
The reason I decided to focus on this rather than just write about the regulators is because there is a HUGE importance to these animal experiments.
#TheRats
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