@SoothSpider 2. When the cellular machinery recognizes this NLS sequence in S protein, the protein is shuttled into the nucleus, where it carries out its function.
@SoothSpider 3. This protein then delivers S mRNA (possibly the whole genome) into the nucleus of the infected cell, resulting in one out of four S proteins translocating into the nucleus in infected cells.
@SoothSpider 4. By accessing this compartment, the S protein is able to modulate virus replication by regulating the synthesis of viral mRNAs and proteins.
@SoothSpider 5. In summary, the NLS sequence βPRRARSVβ of the SARS-CoV-2 S protein allows it to successfully shuttle its mRNA or genome into the nucleus of infected cells, resulting in one out of four S proteins being translocated into the nucleus.
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