6 Tweets 20 reads Mar 22, 2023
Q: 56 years old male with history of chronic back pain
πŸ‘‰ admitted to ICU from the cardiac cath lab after stents for coronary artery disease (CAD).
(NSAIDs) should be avoided in patients with recent cardiac events...
A) True
B) False
Answer: A
NSAIDs are well known for their relative contra-indication in renal insufficiency or acute kidney injury (AKI) in ICU.
Unfortunately, their relative contra-indication in cardiac patients is not always as emphasized.
NSAIDs should be avoided in patients with established CAD due to two reasons.
1.These patients are usually on other anti-thrombotic drugs, such as aspirin or clopidogrel, which highly increases gastrointestinal (GI) bleeding risk.
2. NSAIDs can directly increase the risk of recurrent MI, ischemic stroke or transient ischemic attack (TIA), or systemic arterial embolism with an extremely high hazard ratio (HR) of almost 1:7
Decision making flowchart for the continuation or commencement of COX-2 inhibitors and NSAIDs

Loading suggestions...