@DorissLoh And more.
@DorissLoh There has been some speculation that exogenous melatonin supplementation may result in long-term suppression of endogenous production or pineal gland atrophy.
One old study reported possible suppression of endogenous melatonin in two subjects after twelve weeks.
ncbi.nlm.nih.gov
ncbi.nlm.nih.gov
A more recent systematic review found little to no evidence for adverse events associated with melatonin in this regard.
ncbi.nlm.nih.gov
ncbi.nlm.nih.gov
And a 2018 study reported recovery to normal circadian melatonin rhythms within three days after discontinuation of exogenous melatonin supplementation in two subjects.
ncbi.nlm.nih.gov
ncbi.nlm.nih.gov
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