How Staph aureus manipulates our immune system to cause invasive infections🦠🤒
⭐Inhibits neutrophil extravasation and chemotaxis
⭐Inhibits complement activation and phagocytosis
⭐Inhibits neutrophil-mediated killing
⭐Kills host immune cells
nature.com
1/4
⭐Inhibits neutrophil extravasation and chemotaxis
⭐Inhibits complement activation and phagocytosis
⭐Inhibits neutrophil-mediated killing
⭐Kills host immune cells
nature.com
1/4
⭐Secretes coagulase (remember it's coagulase +ve) and Staph aureus superantigen-like 10 (SSL-10)
➡️Promotes agglutination with fibrin
➡️Protects it from phagocytes
2/4
➡️Promotes agglutination with fibrin
➡️Protects it from phagocytes
2/4
⭐Promotes the release of ATP which is then converted to adenosine
➡️ Inhibits activation of B cells, T cells, macrophages and dendritic cells
⭐Degrades neutrophil extracellular traps (NETs) with nuclease
➡️Triggers formation of caspase 3
➡️Induces apoptosis of macrophages
3/4
➡️ Inhibits activation of B cells, T cells, macrophages and dendritic cells
⭐Degrades neutrophil extracellular traps (NETs) with nuclease
➡️Triggers formation of caspase 3
➡️Induces apoptosis of macrophages
3/4
⭐ Manipulates adaptive immune response
⭐Staphylococcal protein A (SpA)
➡️B cell expansion then apoptotic collapse
➡️Somatic hypermutation of plasmablasts with secretion of non-specific antibodies
⭐T cell superantigen(SAg)
➡️T cell expansion and anergy
➡️Cytokine storm
4/4
⭐Staphylococcal protein A (SpA)
➡️B cell expansion then apoptotic collapse
➡️Somatic hypermutation of plasmablasts with secretion of non-specific antibodies
⭐T cell superantigen(SAg)
➡️T cell expansion and anergy
➡️Cytokine storm
4/4
Loading suggestions...