Thank you Alisha Kabadi (#pccm fellow) for presenting Hydrocortisone in Severe Community-Acquired Pneumonia in @NEJM!
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#MedEd
Learning points:
The use of steroids in community acquired pneumonia has been extensively studied with at least 16 major randomized control trials with variable results; at least 15 meta-analyses have been published on the topic
The use of steroids in community acquired pneumonia has been extensively studied with at least 16 major randomized control trials with variable results; at least 15 meta-analyses have been published on the topic
The βCape Cod" Trial published 3/2023 in @NEJM showed that the hydrocort arm had significantly lower 28-day mortality, intubation, and vasopressors vs. placebo; subgroup analysis showed mixed results in terms of which specific patients would benefit most from steroids.
While further studies are needed, administration of corticosteroids for CAP may be beneficial in non-intubated critically ill patients, given significant association in reduction of incidence of mechanical ventilation
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