Hey medicine residents.
Lets simplify the commonly used blood components.
1. Whole blood collected from donor is centrifuged by a machine to seperate rbcs from the plasma(platelet rich).
Lets simplify the commonly used blood components.
1. Whole blood collected from donor is centrifuged by a machine to seperate rbcs from the plasma(platelet rich).
2. The rbcs form the packed cell volume which is usually transfused to patients.
3. The platelet rich plasma has everything except rbcs. So next step is again a centrifugation(spin) to seperate platelets and a platelet poor plasma.
4. These platelets are whats used.
3. The platelet rich plasma has everything except rbcs. So next step is again a centrifugation(spin) to seperate platelets and a platelet poor plasma.
4. These platelets are whats used.
Then the plasma left contains all the remaining components like proteins, enzymes, etc along with all coagulation factors. This platelet poor plasma (PPP) is frozen to be known as fresh frozen plasma.
It has albumin, adamts13 enzyme, all coagulation factors. So..
It has albumin, adamts13 enzyme, all coagulation factors. So..
FFPs are used to replace coagulation factors, as replacement fluid in TTP for example etc.
This FFPs if further cebtrifuged seperates a cryoprecipitate and a cryo poor plasma. The cryoprecipitate has concentrated factors 1 (fibrinogen), 8, 13, vwf.
This FFPs if further cebtrifuged seperates a cryoprecipitate and a cryo poor plasma. The cryoprecipitate has concentrated factors 1 (fibrinogen), 8, 13, vwf.
So anybody with deficiency of fibrinogen, factor 8, 13 or vwf, and you dont have the isolated concentrates, cryoppt is a good option.
Cryo poor plasma contains all coagulation factors except factor 8 and vwf. Used sometimes in plasma exchange for TTP/HUS and in resource ..
Cryo poor plasma contains all coagulation factors except factor 8 and vwf. Used sometimes in plasma exchange for TTP/HUS and in resource ..
Limited settings for hemophilia B patients to replace factor 9.
Med residents, you should know approximate volume of blood products so when you are transfusing the patients, you are careful as to avoid volume overload. So..
Med residents, you should know approximate volume of blood products so when you are transfusing the patients, you are careful as to avoid volume overload. So..
Each bag approx volume:
Packed cell - 350ml
FFPs - 250 ml
Platelets - 50 ml
Cryoppt - 30 ml
Adult doses:
Packed cell - 1 bag raises around 1.5g
FFPs - 15 ml/kg / day
Platelets - 6 random units or 1 single donor (mega unit)
Cryoppt - 1 bag for every 10kg of patient weight.
Packed cell - 350ml
FFPs - 250 ml
Platelets - 50 ml
Cryoppt - 30 ml
Adult doses:
Packed cell - 1 bag raises around 1.5g
FFPs - 15 ml/kg / day
Platelets - 6 random units or 1 single donor (mega unit)
Cryoppt - 1 bag for every 10kg of patient weight.
When you order platelets , there are two options in the blood bank. So either they have 6 different bags from 6 different donors called random donor units or by a specific mechanism, one mega unit (equal to 6 random donor units) is extracted from a single donor unit is taken.
So usually single donor unit is preferred as it minimises the chances of exposure to 6 different donors. But anyways platelets are always short in supply.
Another very commonly encountered problem is apart from the rbcs do the platelets need to be of the same blood group or no?
Another very commonly encountered problem is apart from the rbcs do the platelets need to be of the same blood group or no?
See I know your problems guys😹
So FFPs for sure need to be of the same group. 🙂 what if you dont have deserves seperate tweet.
Platelets are fine anyways. You can give any group to anyone including hematology patients. Even 6 different blood group platelets can be given.
So FFPs for sure need to be of the same group. 🙂 what if you dont have deserves seperate tweet.
Platelets are fine anyways. You can give any group to anyone including hematology patients. Even 6 different blood group platelets can be given.
Same group is better tho, if available as it decreases the chances of platelet refractoriness.
I hope this is a very helpful tweet for all of you.
Dont forget to RETWEET for your friends. Spread knowledge.
Keep following for informative tweets. 🫠
I hope this is a very helpful tweet for all of you.
Dont forget to RETWEET for your friends. Spread knowledge.
Keep following for informative tweets. 🫠
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