24 yr old female patient ... p/w general malaise, myalgias, & low-grade fever.
Exam w/malar rash, swelling of the digits, & joint tenderness.
Laboratory w/positive ANA & anti-U1 RNP antibodies.
Diagnosis?
Exam w/malar rash, swelling of the digits, & joint tenderness.
Laboratory w/positive ANA & anti-U1 RNP antibodies.
Diagnosis?
Mixed connective tissue disease (MCTD)
ππ½ rare autoimmune disease diagnosed when a specific antibody known as anti-U1-ribonucleoprotein is present
ππ½ rare autoimmune disease diagnosed when a specific antibody known as anti-U1-ribonucleoprotein is present
πthere are features of at least two connective tissue diseases,
πincluding SLE, systemic sclerosis, polymyositis, dermatomyositis, and rheumatoid arthritis.
πincluding SLE, systemic sclerosis, polymyositis, dermatomyositis, and rheumatoid arthritis.
Diagnosis can be challenging due to variable and diverse symptoms upon presentation and the changes in symptoms over time.
NSAIDs, steroids, and immunosuppressive agents are mainstays of treatment
NSAIDs, steroids, and immunosuppressive agents are mainstays of treatment
EPOS
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