💥CLSI M100 34rd Edition
Updates 👇 - A thread 🧵
#MicroRounds #IDXPosts #IDTwitter
(a bit late because I’m 🤒)
Updates 👇 - A thread 🧵
#MicroRounds #IDXPosts #IDTwitter
(a bit late because I’m 🤒)
-Tables 1 and Tables 2 (general) : Renumbered so that each Table 1 has a corresponding Table 2
-Tables of gram positive and gram negative Anaerobes are now combined in Table 1J
-Tables of gram positive and gram negative Anaerobes are now combined in Table 1J
-Table 2A-2 is now a new specific table for Salmonella and Shigella
*** and comment ***
« Data regarding whether amoxicillin should be used to treat shigellosis are conflicting. When reporting results, state that treatment of shigellosis with amoxicillin might have poor efficacy compared with treatment with ampicillin »
*** and comment ***
« Data regarding whether amoxicillin should be used to treat shigellosis are conflicting. When reporting results, state that treatment of shigellosis with amoxicillin might have poor efficacy compared with treatment with ampicillin »
Neisseria meningitidis : drugs to test/report (Table 1I)
Tier 1; Penicillin, Cefotaxime or Ceftriaxone
Tier 4; Meropenem (and ppx only = Azi, FQ, Mino, TMPSMX, Rifampin
Tier 1; Penicillin, Cefotaxime or Ceftriaxone
Tier 4; Meropenem (and ppx only = Azi, FQ, Mino, TMPSMX, Rifampin
-Broth disk elution method for aztreonam plus ceftazidime-avibactam (Table 3D)
-Modified Carbapenem Inactivation methods (Table 3C); Indeterminate now called «Inconclusive»
-Modified Carbapenem Inactivation methods (Table 3C); Indeterminate now called «Inconclusive»
-Test for Performing DD Directly from Positive Blood Culture Broth (Table 3F-1)
*Enterobacterales : Cefepime added (16-18h), revised breakpoints Tobramycin (8-10h, 16-18h)
*P.aeruginosa: Cefepime added (16-18h), revised breakpoints Tobramycin (8-10h, 16-18h)
*Acinetobacter spp added;
Amp-Sulbactam, Cefepime, Ceftazidime, Ceftriaxone, Cipro, Mero, Tobra, TMPSMX
(all 8-10h or 16-18h, except Amp-Sulb and Ceftazidime only 16-18h)
*Enterobacterales : Cefepime added (16-18h), revised breakpoints Tobramycin (8-10h, 16-18h)
*P.aeruginosa: Cefepime added (16-18h), revised breakpoints Tobramycin (8-10h, 16-18h)
*Acinetobacter spp added;
Amp-Sulbactam, Cefepime, Ceftazidime, Ceftriaxone, Cipro, Mero, Tobra, TMPSMX
(all 8-10h or 16-18h, except Amp-Sulb and Ceftazidime only 16-18h)
Many other changes/reformatting/relocations not mentioned here (ex; Tables) ….
➡️Breakpoints
-Acinetobacter spp : new DD and MIC for Sulbactam-durlobactam
-Staph aureus : new DD for Tedizolid, new DD for Linezolid (read with reflected light, previously with transmitted light)
-GAS, GBS, S.anginosus : new DD for Tedizolid
-Acinetobacter spp : new DD and MIC for Sulbactam-durlobactam
-Staph aureus : new DD for Tedizolid, new DD for Linezolid (read with reflected light, previously with transmitted light)
-GAS, GBS, S.anginosus : new DD for Tedizolid
➡️Breakpoints
-Burkholderia cepacia complex : removed DD for Ceftazidime /Meropenem / Minocycline / TMPSMX
-Stenotrophomonas maltophilia : removed MIC for Ceftazidime
-Stenotrophomonas maltophilia : new DD and MIC for Minocycline
*** and comment ***
« TMP-SMX should not be used alone for antibiocrobial therapy»
-Burkholderia cepacia complex : removed DD for Ceftazidime /Meropenem / Minocycline / TMPSMX
-Stenotrophomonas maltophilia : removed MIC for Ceftazidime
-Stenotrophomonas maltophilia : new DD and MIC for Minocycline
*** and comment ***
« TMP-SMX should not be used alone for antibiocrobial therapy»
The End.
(I have probably missed I few things not relevant in my practice/place of work)
(I have probably missed I few things not relevant in my practice/place of work)
p.s. no pictures of the document because of ©️ 🤷♂️
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