MEinSEATTLE
MEinSEATTLE

@emmydugas

8 Tweets 30 reads Mar 19, 2024
1. LDN
2. Ketotifen
3. Cromolyn
4. Amlexanox
My compounding pharmacist is very knowledgable about MECFS. When picking up my ketotifen compound, he spoke to me about 4 foundational drugs that he believes helps our kind with MCAS. 1/ #MECFS
Amlexanox. Is anyone familiar with this mast cell stabilizer?
He recommends them all being compounded into solutions we are less likely to react to; which also makes it easier for us to titrate up the dosage. Low and Slow. #MECFS
1/ This is a quote from an interview b/n 2 drs discussing amlexanox:
"And we have found that if we start using two of the peptides in particular, in fact actually, one of them called amlexanox is small like a peptide. It’s a small molecule, ...
2/...technically it’s not exactly a peptide because it’s got another chemical in it other than just an amino acid. But it’s, again, it’s a very small molecule and so we consider it a peptide. But amlexanox is a medicine originally developed in Japan for aphthous ulcers and is ...
3/...now licensed there for treating asthma and allergies. It’s not licensed in US for that, but we can get it from compounding pharmacies. It tends to mellow the immune response, those mast cells, in a very gentle way without the side effects of many of the antihistamines, ...
4/...which lead people tired and kind of drugged, like, okay. And also a medicine, another peptide called KPV. And if you remember the beginning, I talked about that really big long one, the proopiomelanocortin, which breaks down into melatonin.
5/...And then from that, there’s something, well, actually, the thing that produces melatonin, something called MSH. And a little piece of that is called KPV, just three amino acids. But it has a lot to do with quieting the immune response and getting it to be more balanced.

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