Not much fun without muscle biopsy pictures to look at.
Not the first time we have observed a virus that depletes CD4 cells, persistence and inverted CD4:CD8 ratios lead to autoimmunity, there is an aversion to non-pharmaceutical interventions, vaccines aren't protective, and there is forward transmission.
Dermatomyositis and HIV
ncbi.nlm.nih.gov
ncbi.nlm.nih.gov
Drawing parallels to ME/CFS ignores the concept of the CD4 nadir, which not only allows for opportunistic infection presentation, neuropsychiatric complications, wide spread cortical thinning, it also contributes to autoimmunity.
1. High (>500) Initial presentation of some autoimmune disease
2. Normal/low (200ā499) Immune complex formation, vasculitis
3. Low (<200) CD8+ cell predominant
rheumatologic illnesses
4. High (>500) Resurgence of once quiescent disease
2. Normal/low (200ā499) Immune complex formation, vasculitis
3. Low (<200) CD8+ cell predominant
rheumatologic illnesses
4. High (>500) Resurgence of once quiescent disease
Our failure to engage in drug repurposing leaves little prospect of correct the inversion by allowing CD4 normalization or reducing CD8 elevation due to persistence.
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