🧵1/ Since 2021, after we first published our proteomics paper showing that Long COVID patients have amyloid “microclots” in circulation, I have been amazed by the support from patients, clinicians, and researchers. Here's what we've discovered so far:
🧵2/ These amyloid microclots are found in platelet-poor plasma, and they're resistant to enzyme digestion in Long COVID cases.
🧵3/ Proteomics analysis showed these deposits contain fibrinogen chains, alpha-2-antiplasmin, cytokines, VWF, complement, and even antibodies.
🧵4/ Microclots contribute to thrombotic endothelialitis, which may be central to the symptoms experienced in Long COVID.
🧵5/ Microclots are not a stand-alone “hypothesis,” but contribute together with viral persistence, auto/antibodies, hormone dysregulation, amyloid deposits in muscles, etc.
🧵6/ Alongside the support, I've also faced some harsh criticism from a few authoritative commentators. Why is this surprising?
🧵7/ Some criticisms stem from the fact that clinicians are using our observations to treat patients with anticoagulants and apheresis-type methods. Numerous patients have reported significant relief from these treatments, highlighting the urgent need for clinical trials.
🧵8/ Our goal should be expanding understanding and seeking answers together. Disagreeing with findings? Let's repeat experiments or propose new ones!
🧵9/ Why label them “particles” instead of “clots” if fibrinogen chains are present? Does changing terminology lessen their harm to Long COVID patients?
🧵10/ The argument that “if it’s in other diseases too, it means nothing” puzzles me. Would this logic apply to cholesterol or CRP?
🧵11/ As a scientist, I report what I observe, develop new methods, and share findings with excitement. Constructive engagement should be our norm.
🧵12/ Why did I write this post: not because I want to “prove” who is right or wrong; but because we need to look further, harder, and longer to find answers for the community of suffering patients.
🧵13/ Throughout history, many new findings have faced disbelief and ridicule. Despite this, my commitment to seeking and sharing knowledge remains unwavering. It's in my nature to explore and share insights enthusiastically.
🧵14/ It's a hunt for answers, even when some critics—be it a Fox or a Woof—seem determined to bay at the findings. Let's push the boundaries of knowledge together and strive for a better understanding of Long COVID. 🔬 #LongCOVID #Science #Research #Microclots
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