George Ferman
George Ferman

@Helios_Movement

33 Tweets 3 reads Jul 22, 2024
It is estimated that 1 in 7 American adults has kidney disease and almost half don't even know it.
So if you haven't been able to improve a certain health issue such as fatigue to the degree that you'd like to, maybe it's time to pay attention to the health of your kidneys🧵
*Standard disclaimer that nothing in this thread should be used as a substitute for medical advice*
Gm. It’s George and what we are going to do in this long thread is discuss a lot of cool stuff such as:
-The main functions that the kidneys are responsible for
-Their main parts
-What’s gout and some underrated tips regarding it
-How to check if your kidneys are healthy
-The main and most common things that harm the kidneys
-Underrated supplements AND foods regarding kidney health in general
-And even topics such as if you should worry about protein, oxalates and things of this nature
So i'm pretty confident that spending the next 10-15 minutes of your time reading this will be worth it.
Let's begin.
Under the lower ribs in the posterior abdomen behind the peritoneum (if you are familiar with vertebrae, your kidneys extend from T12 to L3) we have these bean shaped organs that weigh roughly 130-140 grams and have a 10-14 cm long if you are a man and weigh 110 grams and are 9-13 cm long if you are a woman (this does not mean that they can weigh more and for someone to still have healthy kidneys since someone's height weight and so on will affect the size of them) called the kidneys that are also usually around 2-3 cm thick and 5-7cm in wide.
As we will see very soon these little organs are vital for our health and paying more attention to them could be the missing puzzle piece/link that will allow you to further improve your health.
But first, let's talk about kidney's overall structure and break down the function of main parts since being aware of them is very important.
After all, it's a common mistake of trying to fix something in the human body without knowing how that part even works which obviously makes no sense and it's as ridiculous as it sounds.
But don't worry we will mention the absolute basics and the boring part will be done in a few minutes.
Now the kidneys are "covered" by layers of fat and fascia that include (starting at the top of the kidneys) the renal capsule, the perirenal fat, the renal fascia and finally the pararenal fat.
-The renal (or kidney) cortex (the outer layer) which creates EPO, surrounds the medulla and is the starting place for nephrons (each kidney contains millions of them that contain blood vessels called glomerulus that filter the blood)
-The renal medulla (the inner part) that contains the majority of the nephrons.
-The renal capsule (layers of fat and connective tissue that cover the kidneys)
-The renal artery is a blood vessel that controls the blood flow towards the kidneys
-The renal pelvis that gathers and passes urine towards the ureters
-The renal vein is a blood vessel that carries the blood that's been filtered back to the heart
-The renal papilla that also transfers urine to the ureters as well.
So blood enters the kidneys through the renal arteries then smaller arteries and eventually the blood vessels called afferent arterioles that supply blood to the nephrons.
The nephrons have this tube-like structure and are very small (their ranges from 35-55mm) we have over 2 millions of them in total.
They are the functional units of the kidneys but also the structural.
We have two types.
The main ones (meaning that they comprise almost 80% of the total nephrons) are called cortical nephrons (they are present within the cortex) and the rest are called juxtamedullary nephrons.
When you see the term "renal corpuscle" that's just the glomerulus and the Bowman's capsule and when you see the term "renal tubule" that's the proximal convoluted tubule, loop of Henle, distal convoluted tubule, and collecting duct which are components of the nephron.
The renal corpuscle and tubule are also often referred to as the major portions of the nephron so keep that in mind as well.
In the beginning of the nephron we have the glomerulus which is a network of small blood vessels.
When it comes to the Bowman's capsule, each nephron has a network of capillaries called glomerulus that Bowman's capsule covers. It's also made from podocytes and simple squamous epithelium.
The proximal convoluted tubule helps with PH regulation, reabsorption and secretion of various solutes and water such as the filtered bicarbonate, glucose, proteins and amino acids for example.
The loop of Henle basically helps us regulate the volume of extracellular fluids and regulate the composition of the urinary protein.
The distal convoluted tubule is the final part of the nephron (it sends its content to the collecting ducts) and also helps us regulate the volume of extracellular fluids and with the homeostasis of electrolytes and especially magnesium.
And the collecting duct also plays a part in the reabsorption of fluids but also their excretion. For example, it collects urine from the nephrons and sends it to the ureters and the renal pelvis.
But you're probably getting bored with this basic anatomy so here's why the kidneys are SUPER important for our overall health.
If you are going to remember just one thing regarding the nephrons, keep in mind that kidneys filter blood with their help and that the first step is been done through the glomeruli and that diffusion is done through the renal tubules.
So: Blood -> renal artery -> kidneys/renal hilum -> nephrons -> the filtered blood goes back to the bloodstream through the renal vein -> the waste goes to the urine.
Now the major functions of the kidneys include:
-The production of glucose.
Even though our liver is responsible for this for the most part, the kidneys play a part in this process as well and we started with this since it's the most underrated/neglected one of their functions.
-Filtering our blood supply (every 1/2 an hour our entire blood supply gets filtered) and helping us excrete waste products that come from stuff such as the foods we eat and nitrogen from urea for example.
-Controlling the PH balance of our blood.
-Making hormones such as renin (a hormone that helps us regulate our blood pressure), erythropoietin (a hormone that stimulates the bone marrow to make red blood cells) and calcitriol (which is the active form of vitamin D).
-Regulating the amount of fluids that are outside the cells and balancing fluids overall.
-Balancing calcium and phosphate.
-Helping in the metabolism and clearance of leptin.
-Helping (a tiny bit/still not very well understood) the metabolism of histamine.
So if we have unhealthy kidneys, all of these take are negatively impacted and imagine for example the chronic impact that not being able to remove waste products or properly regulate our blood pressure has on our health for example.
So what should a person do?
First of all, even though being aware of certain symptoms that diseases can be useful, general symptoms such as dry skin for example and joint pain can have 1000 different causes.
So always go and test.
What should you test?
Here's a basic panel (do not workout for 2 days prior of getting this):
-OAT
-EGFR
-Creatinine
-BUN
-Albumin
-Globulin
These are non negotiable, now other things that you can add include:
-Calcium
- Phosphorus
- Calcium
-Sodium
-Potassium
-Bicarbonate
-Chloride
-Magnesium
-Glucose
But hold on, is there any proof that kidney dysfunction can lead to the problems that we mentioned in the title of this?
Well, if someone goes a bit back and see the functions that the kidneys are responsible for, then most of the things mentioned in the title make total sense.
But what about the rest such as hair loss?
Something that everyone who is serious about improving a health issue has come to terms with is that he or she will need to address multiple things.
So, kidney dysfunction is not the main cause of someone's hair loss most likely but we know that hyperuricemia is associated with androgenetic alopecia so paying more attention to kidney health might as well be a critical step towards improving ones hair loss.
pubmed.ncbi.nlm.nih.gov
And if you do not believe that hair loss can't have causes outside the typical "genetics" or "DHT":
researchgate.net
Anyway, let's move on to what will harm the kidneys in general (every one of them is kind of linked to the rest so view it as a lifestyle approach).
DISCLAIMER: You will need to keep these in mind for gout as well.
Anyway. Let’s get into it.
Number 1: Glyphosate
We will start with this one since it is unfortunately not mentioned even to the people who have some form of kidney disease but it's a very important one and this study simple to go through.
sciencedirect.com
Besides this, glyphosate also contributes to the oxalate load and also negatively affects our gut health so it harms the kidneys both in direct ways but also indirect but equally dangerous.
data.epo.org
But glyphosate presents multiple problems for our health as we've discussed many times so it's a good idea to avoid it even if your kidneys are fine.
Number 2: Insulin resistance
academic.oup.com
ncbi.nlm.nih.gov
12 things that could help someone avoid insulin resistance include:
0. Eating your meals under natural light.
1. Focusing on gut health and especially address possible pathogen-related issues.
2. Not consuming bad fats and replace them with things such as grass fed tallow, ghee, EVOO and coconut oil.
3. Quitting alcohol.
4. Avoiding artificial blue light and get more sunlight.
5. Replenishing B vitamins and minerals.
6. Resistance training for 60 minutes every 48 hours and walk daily.
7. Maintaining a healthy bw obviously.
8. Not eating huge meals at night since melatonin, upon its release decreases the function of the pancreas.
9. Going to bed before 11 P.M.
10. Grounding as much as i could throughout the day.
11. Not smoking.
12. Getting enough vitamin K.
Number 3: Deficiencies
Tens of thousands of processes in the human body are based on micronutrients so if we don’t provide enough of them problems will happen.
Something as sleep as a zinc deficiency for example can negatively affect our hormones but also even our sleep.
ncbi.nlm.nih.gov
Now, the main nutrients that if we don’t get enough will negatively affects the kidneys are:
-Magnesium
-Potassium
-Sodium (yes, you need sodium in order to not aldosterone max)
-B vitamins
-Calcium
-Molybdenum
-Vitamin D
-Selenium
Let’s take thiamine for example:
sciencedirect.com
ncbi.nlm.nih.gov
ncbi.nlm.nih.gov (this one is not just for thiamine)
Regarding B6, it is required for the conversion of glyoxalate to glycine.
Then selenium is crucial for glutathione when intracellular glutathione is depleted the formation of oxalate increases quite a lot.
Regarding molybdenum we need it in order to detoxify uric acid.
But this does not mean that you should SUPPLEMENT all of these nutrients.
Use food first:
x.com
Number 4: Overdoing it with grains and especially whole grains.
You don’t need 6 servings of grains per day or what the recommended amount is these days.
That’s ridiculous and you’ll end up consuming too much phosphorus that needs to be balanced with calcium not to mention that if we are talking about stuff such as wheat, we could be facing more problems.
*You can consume stuff such as spelt or einkorn bread. Just get a quality one and pair them with something that has calcium*
Number 5: The over-use of antibiotics and not taking care of the gut overall.
Let’s approach this from two angles.
The first one will be issues such as candida since they are very common but they will add to the total oxalate production and then harming beneficial bacteria such as lactobacillus will also create problems since they degrade purines in the blood.
journals.physiology.org
ncbi.nlm.nih.gov
jrnjournal.org
Number 6: Consuming way way too many oxalates.
Now i eat foods that are high in oxalates such as kiwis and berries since they are great micronutrient sources, but things such as green supplements that have way way too many oxalates and also overdoing it with all foods are very popular these days and both of these will causes issues.
If you for example, eat a pound of berries, 3 handfuls of almonds or something similar, ¼ of a pound of cacao, put turmeric on everything and take a green supplement, then the total amount of oxalates is insane.
Number 8: Harmed bile flow
Poor bile flow is a very underrated cause of reacting badly to oxalates since one of the functions of conjugated bile acids is preventing the reabsorption of oxalates.
The easiest first steps you can take in order to secure proper bile flow include:
-Moving believe it or not
-Getting enough choline
-Getting enough vitamin C
-Getting enough taurine
-Getting enough glycine
-Not “fasting” with black coffee daily
-Respecting your circadian rhythm
(ncbi.nlm.nih.gov…)
Having proper bile flow overall is of course crucial for our gut and liver health.
Number 9: Using NSAIDs/aspirin for no real reason
researchgate.net
pubmed.ncbi.nlm.nih.gov
pubmed.ncbi.nlm.nih.gov
It is in fact that aspirin can have benefits but when something has benefits we should as ourselves if there’s something safer that has the same benefits and in the case of aspirin we have things such as cistanche or thiamine.
Number 10 : Alcohol and machine lubricants such as canola oil.
That's pretty simple. Alcohol will negatively affect the elimination of uric acid the more you drink, the more your kidneys will get damages and these fats will harm our ability to get rid of oxalates.
Number 11: Poor methylation
This is mainly related to B6, B12, glutathione and histamine.
You need to get tested for this one (type my handle and histamine next to it).
Number 12: Too many carbs
Now there’s nothing wrong with seasonal carbs. They are great tools full of nutrients such as vitamin C that can help us perform better in the gym and so on.
But even though a lot of people with kidney issues are aware that uric acid is a byproduct of the metabolism of purines and try to avoid meat altogether (which can be a mistake), they forget that when our bodies breaks down fructose for example, the amount of purines that’s released is WAY larger than the one from a piece of meat.
So, if you weight 180 pounds for example and live a sedentary lifestyle, don’t consume 600 grams of carbs (that’s way more common than someone might think).
Now do i suggest going no carb? If you have no kidney issues then not really if you do everything else that’s suggested here.
If you have issues such as gout, going keto or cycling it could come into play as we will later see.
OXALATE TIP: If you are super sensitive, once you address the root causes of the dysfunction (gut issues, deficiencies, poor bile flow, bad fats etc) and start reintroducing things such as rasbeprries or kiwis for example, don’t only pair them with the typical calcium but ALSO magnesium since calcium oxalate and urinary oxalate will lead to magnesium oxalate.
Number 14: Dehydration
x.com
"Okay, but how about protein? Won't too much protein harm my kidneys?"
It depends. If you weight 170 pounds and consume 4 pounds of GMO chicken or you consume 100 grams of gelatine and 500 grams of collagen per day that's not that great.
Overall? No and there are many studies presented down below. But that being said, going lower on purines can have benefits.
link.springer.com
ncbi.nlm.nih.gov
frontiersin.org
care.diabetesjournals.org
Now let's talk about GOUT and more specifically underrated causes and undervalued tools since i'll make more posts specifically about GOUT in the future.
The first underrated tool is lactobacillus since it degrades purines.
The second is clostridium which is low in people with hyperuricemia.
The third is GROUNDING since inflammatory cytokines are increased a lot before and during a gout attack.
*NAC can be added here as well*
Now here are more cool things:
-Near-iron deficiency-induced remission of gouty arthritis
pubmed.ncbi.nlm.nih.gov
-Bloodletting therapy.
sciencedirect.com
"Remission of gouty arthritis by phlebotomy (bloodletting or blood donation) "gouty attacks markedly diminished in every patient" by about 80%."
More:
academic.oup.com
rheumatology.oxfordjournals.org
academic.oup.com
Keto?
sciencedirect.com
crownmd.net
How about supplements?
Well this can be tricky and you should listen to your doctor.
In general we have:
-Taurine
-Thiamine
-Magnesium
-Quercetin
-Astragalus
-Ginger
That's pretty much it.
Make sure to leave a like/RT if you learned something from this thread.
x.com

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