8 Supplements that Instantly Crush Anxiety
Thread🧵
Thread🧵
Anxiety can be a natural, normal response to perceived threats or stressful events
Although, issues arise when it becomes excessive, irrational, or persistent, impacting our day to day functioning and making it harder to sleep/relax, etc
Although, issues arise when it becomes excessive, irrational, or persistent, impacting our day to day functioning and making it harder to sleep/relax, etc
The symptoms of anxiety are thought to result from an imbalance of neuronal activity in emotion processing structures of the brain, specifically the amygdala
Usually, its a hyperactivity of these areas caused by decreased GABA signaling and/or increased glutamate signaling
Usually, its a hyperactivity of these areas caused by decreased GABA signaling and/or increased glutamate signaling
As a result, the easiest way to combat anxiety is to reduce excitatory (glutamate) signaling and increase inhibitory (GABA) signaling in the brain to directly and instantly reduce symptoms
Which is exactly what all of the supplements on this list will do in one way or another
Which is exactly what all of the supplements on this list will do in one way or another
Disclaimers:
None of the information in this thread is medical advice. I am not a doctor, let alone your doctor. Always do your own research
This thread contains affiliate links which will earn me commission if you choose to use them, but it comes with no additional cost to you
None of the information in this thread is medical advice. I am not a doctor, let alone your doctor. Always do your own research
This thread contains affiliate links which will earn me commission if you choose to use them, but it comes with no additional cost to you
1) Mulungu Bark
Mulungu, aside from being really fun to say, has become one of my favorite sleep supplements recently
It’s a more obscure herb, but it’s been garnering a lot of attention on X lately, and for good reason
Mulungu, aside from being really fun to say, has become one of my favorite sleep supplements recently
It’s a more obscure herb, but it’s been garnering a lot of attention on X lately, and for good reason
It has the unique ability to inhibit nicotinic acetylcholine receptors alongside some GABAergic activity, making it a potent anxiolytic
Even in small quantities it has the ability to quiet a racing mind
Even in small quantities it has the ability to quiet a racing mind
I get my Mulungu bark from my good friend @Grimhood's shop (which I have no affiliation with)
I highly recommend checking it out if your interested in procuring whole herbs, or some incredible premade herbal blends/tinctures
Link here:
grimmsapothecary.net
I highly recommend checking it out if your interested in procuring whole herbs, or some incredible premade herbal blends/tinctures
Link here:
grimmsapothecary.net
2) Magnesium
Magnesium is one of those supplements that everyone should be taking daily
It’s involved in thousands of bodily processes, but most people are deficient
Because of that, a lot of people feel immediate anxiety relief when they start taking it
Magnesium is one of those supplements that everyone should be taking daily
It’s involved in thousands of bodily processes, but most people are deficient
Because of that, a lot of people feel immediate anxiety relief when they start taking it
Why?
- NMDA receptor blockade
- GABA support
- Metabolism support
- & much more
For those interested, I wrote more in depth about magnesium's primary anti-anxiety role in the brain here
x.com
- NMDA receptor blockade
- GABA support
- Metabolism support
- & much more
For those interested, I wrote more in depth about magnesium's primary anti-anxiety role in the brain here
x.com
The most potent magnesium form for combatting anxiety is going to be acetyl-taurate. Other forms like chloride and glycinate are great for daily use
Magnesium acetyl-taurate is available commercially as the patented "Tauromag"
lddy.no
Magnesium acetyl-taurate is available commercially as the patented "Tauromag"
lddy.no
3) L-Theanine
Theanine is an amino acid found naturally in green tea, and a personal favorite of mine
It works great as a general anti-anxiety tool and is able to enhance alpha brain wave power in the brain which can indicate reduced stress and increased relaxation
Theanine is an amino acid found naturally in green tea, and a personal favorite of mine
It works great as a general anti-anxiety tool and is able to enhance alpha brain wave power in the brain which can indicate reduced stress and increased relaxation
Theanine primarily works by antagonizing the AMPA glutamate receptor, directly reducing glutamate activity in the brain
This is best paired with magnesium for that combined AMPA & NMDA receptor antagonism (check out the post on magnesium and the NMDAR above for more on this)
This is best paired with magnesium for that combined AMPA & NMDA receptor antagonism (check out the post on magnesium and the NMDAR above for more on this)
It also pairs exceptionally well with caffeine to smooth out its stimulatory effects and provide a calm focus
You can get theanine in a bulk powder form or in capsules for really cheap on amazon or elsewhere
You can get theanine in a bulk powder form or in capsules for really cheap on amazon or elsewhere
4) Magnolia Bark
Bark from the Magnolia officinalis tree has been used for thousands of years for its anti-anxiety properties
It’s 2 main active compounds, magnolol and honokiol, are potent GABA receptor modulators
Bark from the Magnolia officinalis tree has been used for thousands of years for its anti-anxiety properties
It’s 2 main active compounds, magnolol and honokiol, are potent GABA receptor modulators
Basically, they bind to GABA receptors and enhance their function, similar to Xanax (just less potent)
Magnolia bark can be used as the whole bark (as part of a tea for example) or as an herbal extract supplement
Magnolia bark can be used as the whole bark (as part of a tea for example) or as an herbal extract supplement
If you go for an extract, look for one with a high % of magnolol and honokiol like this one from Nootropics Depot
lddy.no
lddy.no
5) Taurine
Taurine, like theanine, is a simple amino acid that has inhibitory effects in the brain
Unlike theanine however, it is found predominantly in animal products and acts directly on GABA receptors as a means of reducing anxiety
Taurine, like theanine, is a simple amino acid that has inhibitory effects in the brain
Unlike theanine however, it is found predominantly in animal products and acts directly on GABA receptors as a means of reducing anxiety
The list of taurine’s benefits is a mile long, including but not limited to;
-Antioxidant
-Enhances exercise performance
-Enhances energy metabolism
But its inhibitory action in the brain makes it a great anxiolytic tool
-Antioxidant
-Enhances exercise performance
-Enhances energy metabolism
But its inhibitory action in the brain makes it a great anxiolytic tool
Taurine can also be found for extremely cheap in bulk powder form
6) Agmatine Sulfate
Agmatine is a molecule that’s naturally produced in the body from the amino acid arginine
It has a few mechanisms of action, but most notable for the purposes of anxiety are going to be those that decrease glutamate signaling
Agmatine is a molecule that’s naturally produced in the body from the amino acid arginine
It has a few mechanisms of action, but most notable for the purposes of anxiety are going to be those that decrease glutamate signaling
That's going to be:
- NMDA receptor antagonism
- nNOS inhibition
More specifically, both of these mechanisms are great for halting glutamatergic positive feedback loops
More on that specifically in this post
x.com
- NMDA receptor antagonism
- nNOS inhibition
More specifically, both of these mechanisms are great for halting glutamatergic positive feedback loops
More on that specifically in this post
x.com
Agmatine can also be purchased for cheap in capsule form or in bulk as a powder
7) Lemon Balm
Lemon balm is an herb that’s famous for its calming effects
As part of a tea or as an herbal extract supplement, lemon balm greatly increases levels of GABA in the brain by inhibiting the enzyme that normally breaks down GABA
Lemon balm is an herb that’s famous for its calming effects
As part of a tea or as an herbal extract supplement, lemon balm greatly increases levels of GABA in the brain by inhibiting the enzyme that normally breaks down GABA
Because of this it is a highly effective anti-anxiety tool, and is highly synergistic with other compounds that enhance GABA activity at the receptor level like magnolia bark or number 8 on this list
I use this extract from ND. Its potent enough that just half a tablet is enough most of the time, especially if used in conjunction with any other GABAergic supplement
lddy.no
lddy.no
8) Apigenin
Apigenin is the primary compound in chamomile tea responsible for its calming properties
Like magnolia bark, it's anti-anxiety mechanism is positively modulating the GABAA receptor, enhancing the action of endogenous GABA
Apigenin is the primary compound in chamomile tea responsible for its calming properties
Like magnolia bark, it's anti-anxiety mechanism is positively modulating the GABAA receptor, enhancing the action of endogenous GABA
I prefer to get apigenin from chamomile tea, but there are supplements of pure apigenin available out there
Reminders:
1. Keep in mind not to use all of these at once (hopefully obvious)
2. If using herbal extract forms of GABAergic herbs, limit their use to 1-2 times per week to avoid tolerance buildup and GABA downregulation
1. Keep in mind not to use all of these at once (hopefully obvious)
2. If using herbal extract forms of GABAergic herbs, limit their use to 1-2 times per week to avoid tolerance buildup and GABA downregulation
Some references:
PMIDs
Mulungu: 24349349, 17253849, 17268084
Magnesium: 35184264, 33260549
Theanine: 35449538, 31623400
Mag bark: 22771461, 22445602
Taurine: 18171928, 23616711
Agmatine: 28302445, 38608401
Lemon Balm: 19165747, 21076869
Apigenin: 22370792, 10930722
PMIDs
Mulungu: 24349349, 17253849, 17268084
Magnesium: 35184264, 33260549
Theanine: 35449538, 31623400
Mag bark: 22771461, 22445602
Taurine: 18171928, 23616711
Agmatine: 28302445, 38608401
Lemon Balm: 19165747, 21076869
Apigenin: 22370792, 10930722
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