Ramzes Chavez MD
Ramzes Chavez MD

@ChavezRamzes

14 Tweets 4 reads Feb 10, 2025
🧡 Must-Know Signs in Neuroradiology: A Critical Thread for Clinicians & Neurosurgeons
Recognizing key radiological signs in neuroradiology is crucial for accurate diagnosis and management.
The essential "must-know" imaging signs every neurologist, neurosurgeon, and radiologist should recognize. πŸ§ πŸ”
πŸ‘‡
2/ "Sinking Skin Flap Sign" β†’ Syndrome of the Trephined
πŸ“Œ Seen in patients post-craniectomy.
πŸ–₯️ CT/MRI: Sunken scalp flap, underlying cerebral compression.
⚠️ Indicates impaired CSF dynamics & cerebral perfusion.
βœ… Cranioplasty can restore neurological function!
Reference: Shroff MM. Twenty classic signs in neuroradiology: A pictorial essay. Indian J Radiol Imaging. 2009;19(2):135-145.
3/ "Dense MCA Sign" β†’ Early Ischemic Stroke
πŸ“Œ Hyperdense middle cerebral artery on non-contrast CT = early thrombus.
πŸ–₯️ Seen in acute MCA infarcts due to large vessel occlusion.
🚨 Urgent thrombectomy or thrombolysis is needed!
Reference: Koo CK, Teasdale E, Muir KW. What constitutes a true hyperdense middle cerebral artery sign? Cerebrovasc Dis. 2000;10(6):419-423.
4/ "Dural Tail Sign" β†’ Meningioma
πŸ“Œ Thickened, enhancing dura adjacent to a mass.
πŸ–₯️ MRI with contrast shows smooth, extra-axial, homogeneous enhancement.
βœ… High specificity for meningiomas, but can be seen in metastases.
Shroff MM. Twenty classic signs in neuroradiology: A pictorial essay. Indian J Radiol Imaging. 2009;19(2):135-145.
5/ "Swirl Sign" β†’ Active Bleeding in Epidural Hematoma
πŸ“Œ Hypodense area inside a hyperdense epidural hematoma.
πŸ–₯️ Seen on non-contrast CT, indicating ongoing arterial bleeding.
🚨 Neurosurgical emergency β†’ Urgent surgery required!
6/ "Hot Cross Bun Sign" β†’ Multiple System Atrophy (MSA)
πŸ“Œ Cross-like hyperintensity in the pons.
πŸ–₯️ Seen on T2-weighted MRI due to degeneration of pontocerebellar fibers.
⚠️ Suggestive of MSA-C (cerebellar type), a progressive neurodegenerative disorder.
7/ "String Sign" β†’ Carotid Artery Stenosis
πŸ“Œ Severe narrowing of the internal carotid artery (ICA).
πŸ–₯️ Seen on CTA or MRA, indicating critical luminal narrowing.
🚨 High stroke risk! Endarterectomy or stenting may be needed.
8/ "Hummingbird Sign" β†’ Progressive Supranuclear Palsy (PSP)
πŸ“Œ Midbrain atrophy resembling a hummingbird on sagittal MRI.
πŸ–₯️ T1 MRI β†’ Atrophic midbrain with preserved pons.
⚠️ PSP is a parkinsonian-plus syndrome with vertical gaze palsy & postural instability.
9/ "Eye of the Tiger Sign" β†’ Pantothenate Kinase-Associated Neurodegeneration (PKAN)
πŸ“Œ T2 MRI: Central hypointensity (iron accumulation) in the globus pallidus with a hyperintense core.
🧬 Seen in PKAN, a rare neurodegenerative disorder affecting basal ganglia.
10/ "Salt-and-Pepper Appearance" β†’ Paragangliomas
πŸ“Œ Heterogeneous flow voids on MRI due to vascular tumor.
πŸ–₯️ Seen in carotid body tumors, glomus tumors.
βœ… Highly vascular β†’ Angiography & pre-op embolization often required!
11/ "Dawson’s Fingers" β†’ Multiple Sclerosis (MS)
πŸ“Œ Periventricular, ovoid white matter lesions oriented perpendicular to the ventricles.
πŸ–₯️ MRI FLAIR β†’ Seen in MS due to perivenular demyelination.
βœ… Key diagnostic feature for MS (McDonald criteria).
11/ Hockey Stick Sign β†’ Creutzfeldt-Jakob Disease (CJD)
πŸ“Œ MRI DWI/T2: Symmetric hyperintensity in caudate nucleus & putamen.
⚠️ Seen in variant & sporadic CJD (prion disease).
πŸ”— Reference: Vitali P et al. MRI findings in sporadic CJD: The hockey stick sign. Neurology. 2011.
Molar Tooth Sign β†’ Joubert Syndrome
πŸ“Œ Axial T2 MRI: Midbrain-hindbrain malformation, hypoplasia of cerebellar peduncles, and "molar tooth" shape.
⚠️ Diagnostic of Joubert syndrome (genetic ciliopathy).
πŸ”— Reference: Poretti A et al. Molar tooth sign: Diagnostic value in Joubert syndrome. Am J Neuroradiol. 2007
12/ Hockey Stick Sign β†’ Creutzfeldt-Jakob Disease (CJD)
πŸ“Œ MRI DWI/T2: Symmetric hyperintensity in caudate nucleus & putamen.
⚠️ Seen in variant & sporadic CJD (prion disease).
πŸ”— Reference: Vitali P et al. MRI findings in sporadic CJD: The hockey stick sign. Neurology. 2011.

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