Rattibha

𝙼𝚊𝚑𝚍𝚒 𝙰𝚋𝚞 𝙰𝚝𝚝𝚊, 𝙼𝙳🩺

7 Tweets 55 reads Sep 11, 2020

So, here goes my first #medtwitter #tweetorial …
Why does E.COLI sepsis occur in neonatal galactosemia ?
#pediatrics #tweetiatrician
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*Briefly, deficient activity of one of three enzymes results in elevated blood galactose concentration (galactosemia)
*Classic galactosemia, caused by complete deficiency of galactose-1-phosphate uridyl transferase (GALT), is the most common and severe type. #FOAMed
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*It is an autosomal-recessive disorder
*Galactose is a sugar found primarily in human and bovine milk and milk products. #FOAMPED
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Now, how galactosemia related to septicemia?
A review of the pertinent literature, shows an association of galactosemia with life-threatening infection, particularly E.coli sepsis #MedEd
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Here is how..
1. The substrate for the bacteria would be accumulation of galactose in the tissue especially only lactose-fermenting organisms ex E.COLI
2.inhibition of leucocyte bactericidal activity secondary to impairment of cellular release of superoxide ion by galactose
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study of the in vitro effect of galactose on neutrophil function in healthy newborns -
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