9 Tweets 1 reads Jun 14, 2022
"Covid stress" 1/n
As a clinician, this is my shorthand for
-won't leave house bc afraid of covid
-lost job at restaurant bc no business
-won't get vaccine/lost job
-kids at home w/ lockdown/couldn't work
-gained 30 pounds because overate during lockdown
-unwell since vaccine
Covid stress 2/n: General Adaptation Syndrome
(Selye 1936)
Seminal modern study on stress: Selye half-drowned rats and watched effects on body
Adrenal glands grew, thymus gland shrank
Covid stress 3/n: Cures for Stress
Interestingly, despite Selye's discovery, no remedies to downregulate adrenals or upregulate thymus gland ever caught on
A rather strange gap in medicine
However, antihypertensives are huge market, which deal with downstream effect of stress
Covid stress 4/n: time to do a lit search
Many facets to explore: how to measure stress (behaviourally, biochemically, clinically); has "covid stress" been reported in peer-reviewed literature? Causes of stress resilience versus stress breakdown?
"Covid stress"5/n: creating diagnostic construct, psychiatric/psychological perspective
ncbi.nlm.nih.gov
Covid stress 6/n: creating "covid stress scale." Note that this is primarily a psychological/behavioural scale
sciencedirect.com
Covid stress and cortisol: many studies, it appears
7/n
(8/n)Covid stress & cortisol in nurses during first covid wave: study from Slovenia. Interesting method - cortisol in hair. 67 hair samples. Cortisol levels markedly higher during covid wave than prior, regardless of acutal magnitude of cases they managed
sciencedirect.com
(9/n)Covid stress, hair cortisol. Review study on the use of hair for this purpose. Includes partial map of stress response - note that thymus not shown here
link.springer.com

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