Understanding the pathogenesis of hepatic encephalopathy by listening to @DebbieShawcros1 and why you need to think about inflammation in addition to ammonia #ilc2022
#livertwitter ๐งต
@kidney_boy @AvrahamCooperMD
#livertwitter ๐งต
@kidney_boy @AvrahamCooperMD
The gut barrier begins to leak in #cirrhosis and portal hypertension
Bacteria cause inflammation
#ilc2022
Bacteria cause inflammation
#ilc2022
The kinds of bacteria that populate the gut (including the mouth) are nasty nasty bugs
#ilc2022
#ilc2022
The inflammation injures the brain and facilitates transfer across the blood-brain barrier other toxins like ammonia, causing neuronal dysfunction #ilc2022
Putting it all together, rifaximin appears to work by improving the bacterial diversity, restoring elements of the gut barrier and improving immune function (the RifSys trial)
#ilc2022
#ilc2022
As promised a tweetorial on HE on the wonderful, clarifying work from the one and only @DebbieShawcros1 while she presented at #ilc2022
@aelsharkawy75 @RodriguezGandia @jturnesv
@aelsharkawy75 @RodriguezGandia @jturnesv
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