Gregory Brennan, MD
Gregory Brennan, MD

@GBrennanMD

24 Tweets 9 reads Aug 08, 2022
Coffee:
1. stimulates gastric, biliary, and pancreatic secretions.
2. stimulates the motor activity of the colon
3. induces changes in the composition of the gut microbiota.
4. protective effects against liver cancer and all other liver diseases.
5. Decreased risk of stones ( both gallstones and kidney stones)
6. Caffeinated coffee significantly increases colonic motor activity.
7. May trigger the gastrocolonic response or reflex. (This is the urge to defecate soon after or at the start of a meal)
8. Keeping with the motility trend, coffee has been shown to decrease post operative ileus. Even for non GI surgeries (GYN).
May prevent cholesterol gallstone formation by decreasing gallbladder fluid absorption and increasing CCK secretion. This stimulates gallbladder contraction.
10. Coffee is good for your liver:
🔹lower LFTs
🔹decreased fibrosis and fibrinogenesis
🔹decreased risk of cirrhosis
🔹decreased risk of HCC (liver cancer)
11. Decreased risk of most cancers. For GI cancers, it is Inversely associated with risk of CRC (colorectal cancers) in a dose dependent manner.
12. Coffee may reduce the risk of these cancers: melanoma, other skin cancers, breast, prostate, endometrial, colon, liver.
13. Reduces the lower esophageal sphincter pressure and stimulates gastric secretions. This maybe why you hear about avoiding in GERD but evidence is weak related to dietary causes of GERD.
14. Did you know that there is fiber in coffee?đź’ĄAnd fiber is of course important in gut health related to cholesterol absorption, microbiome, and motility.
15. May play a role in the brain-gut axis. It may activate the sympathetic nervous system. (This is beyond the effects of caffeine alone).
16. Decrease risk of Parkinson’s disease. Want to go down a rabbit hole? Look up how Parkinson’s disease may start in the gut!
17. Reduced risk of depression and suicide.
18. Effects on glucose metabolism likely via the liver and decreased risk of type 2 diabetes.
19. Reduce appetite and increase basal metabolic rate
20. Reduced risk of cardiovascular disease:
đź«€coronary artery disease
đź«€stroke
đź«€death from heart attack or stoke
21. Reduced all-cause mortality.
This benefit has been shown in populations all around the world and the benefit is seen regardless of caffeine.
22. The quality of evidence on all these points is very variable.
Most of the benefits of coffee seem to come from 1 of the 1,000s of bio active components. Sometimes it’s caffeine but usually it’s not related.
23. Here’s some sources for these:
nejm.org
👉Coffee is the ultimate “food as medicine.”
👉Coffee fits into a plant based diet.
👉Coffee should be kept as pure as possible don’t add too much animal products (milk, cream etc) or sugar.
👉 long term daily use leads to most benefits.
👉Sweet spot is 1-3 cups daily.

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