🔮 ALL DISEASE BEGINS IN THE GUT (THREAD) 🔮
It is of CARDINAL importance to have a healthy gut. Don't you know?
From Diabetes to Parkinson, Fatty Liver to Depression, Anxiety to Obesity...
All these diseases have Poor Gut Health as a root cause.
Here's why:
It is of CARDINAL importance to have a healthy gut. Don't you know?
From Diabetes to Parkinson, Fatty Liver to Depression, Anxiety to Obesity...
All these diseases have Poor Gut Health as a root cause.
Here's why:
Your intestines harbor trillions of microbial species (mainly bacteria) collectively known as "gut microbiome", which through different molecules it produces & nerves?
Is connected to ALL organs, mainly brain & liver, conferring your gut the ability to regulate their functioning
Is connected to ALL organs, mainly brain & liver, conferring your gut the ability to regulate their functioning
Now, the kind of effects the gut has on our organs will depend on how HEALTHY our gut is. Thus, let's say that you want your brain's ability to focus to get better.
Then, improving your gut microbiome should be a priority.
And if you're dealing with a mental health issue?
Then, improving your gut microbiome should be a priority.
And if you're dealing with a mental health issue?
I guarantee you that your gut microbiome is not at its healthiest state - yet.
Not surprising. Almost every disease is related with bad gut health.
Type 2 Diabetes, Depression, Fatty Liver, Autism, Asthma, Parkinson, even several types of Cancer.
But,
Why?
Not surprising. Almost every disease is related with bad gut health.
Type 2 Diabetes, Depression, Fatty Liver, Autism, Asthma, Parkinson, even several types of Cancer.
But,
Why?
To understand this, we must understand microbiome's functions, how it becomes unhealthy & how this drives disease. Focus will be on gut bacteria - the gut's most abundant microbe.
They act on 4 landscapes of your body:
🧬 Metabolic
🛡 Protective
⛓ Structural
🧠 Neurological
They act on 4 landscapes of your body:
🧬 Metabolic
🛡 Protective
⛓ Structural
🧠 Neurological
Metabolic refers to everything related with the break down, conversion & synthesis of molecules.
Like fiber's break down - after all, our digestive system's enzymes can't break down fibers such as Resistant Starch & Cellulose.
But our Gut Bacteria?
They do it with ease.
Like fiber's break down - after all, our digestive system's enzymes can't break down fibers such as Resistant Starch & Cellulose.
But our Gut Bacteria?
They do it with ease.
As they have A LOT of carbohydrate-active enzymes (CAZy).
We have 97 Glycoside Hydrolases (GHs, group of CAZys) - 17 involved in carb digestion...
But the strain Bacteroides Thetaiotaomicron F9-2?
Synthesizes 299 GHs. Alone.
This is for only ONE strain & ONE group of CAZys...
We have 97 Glycoside Hydrolases (GHs, group of CAZys) - 17 involved in carb digestion...
But the strain Bacteroides Thetaiotaomicron F9-2?
Synthesizes 299 GHs. Alone.
This is for only ONE strain & ONE group of CAZys...
Imagine the whole microbiome together!
CAZys allow our bacteria ferments, feeds on & breaks down fiber for us,
This results in Short Chain Fatty Acid (SCFA) production, which have several roles/benefits.
From being THE energy of our intestinal cells to Neurogenesis 👇
CAZys allow our bacteria ferments, feeds on & breaks down fiber for us,
This results in Short Chain Fatty Acid (SCFA) production, which have several roles/benefits.
From being THE energy of our intestinal cells to Neurogenesis 👇
Other metabolic roles of the gut are initiating fat digestion & synthesis of vitamins, amino acids & neurotransmitters:
When lipids are present in the intestines, the microbiome & enteroendocrine cells increase Cholecystokinin to release Bile so lipids get digested.
Also...
When lipids are present in the intestines, the microbiome & enteroendocrine cells increase Cholecystokinin to release Bile so lipids get digested.
Also...
- 50% of Vit K's Required Daily Intake
- 86% of B6's RDI
- 37% of B9's RDI
- 27% of B3's RDI
Can be synthesized by the microbiome.
And up to
- 19-22% of circulating Leucine
- +90% of Serotonin &
- +46% of Dopamine in your body
Originate in the gut, shoutout to the microbiome
- 86% of B6's RDI
- 37% of B9's RDI
- 27% of B3's RDI
Can be synthesized by the microbiome.
And up to
- 19-22% of circulating Leucine
- +90% of Serotonin &
- +46% of Dopamine in your body
Originate in the gut, shoutout to the microbiome
If you nourish your gut, your gut will nourish you. Simple as bruv.
And talking about neurotransmitters...
The microbiome achieves its Neurological role thanks to the vagus nerve - connects the gut to major organs including the BRAIN,
Thus creating the Gut-Brain Axis, allowing bidirectional communication.
But 80-90% of the vagus nerve fibers?
The microbiome achieves its Neurological role thanks to the vagus nerve - connects the gut to major organs including the BRAIN,
Thus creating the Gut-Brain Axis, allowing bidirectional communication.
But 80-90% of the vagus nerve fibers?
Are dedicated to send nerve impulses only FROM the gut to the brain!
Our gut is a key player in brain function.
The microbiome mainly transmits our food intake & satiety status, but Its also IMPERATIVE to sustain & improve brain health; it regulates Neurogenesis, Myelination,
Our gut is a key player in brain function.
The microbiome mainly transmits our food intake & satiety status, but Its also IMPERATIVE to sustain & improve brain health; it regulates Neurogenesis, Myelination,
Neuronal migration, Blood-Brain-Barrier & Microglia's ("immune brain cells") reaction.
Though achieved through several ways, SCFA production is among the main ones.
For ex, A pathogen gets to the brain, activating Microglia. Thus, inflammatory genes get expressed, producing-
Though achieved through several ways, SCFA production is among the main ones.
For ex, A pathogen gets to the brain, activating Microglia. Thus, inflammatory genes get expressed, producing-
& releasing Inflammatory cytokines, causing neuroinflammation. Overtime this causes Axon Degradation, BBB permeability, neuron death..
But the SCFA butyrate?
In the brain INHIBITS inflammatory genes AND activates ANTI-inflammatory genes, protecting the brain from those effects.
But the SCFA butyrate?
In the brain INHIBITS inflammatory genes AND activates ANTI-inflammatory genes, protecting the brain from those effects.
butyrate a real one fr fr💯
If I go balls deeper on gut-brain connection this thread would have 10 more tweets lmao, let's leave that for another poast
which like this thread, my based patreons will have early access to, join now baby cmon
patreon.com
If I go balls deeper on gut-brain connection this thread would have 10 more tweets lmao, let's leave that for another poast
which like this thread, my based patreons will have early access to, join now baby cmon
patreon.com
Now,
A healthy microbiome carries out effortlessly it's demanded functions in these 2 landscapes, and will go beyond that, producing an abundance of SCFAs & vitamins, thus benefiting the host in several ways.
From improved nutrient absorption, gut motility, evacuations, to-
A healthy microbiome carries out effortlessly it's demanded functions in these 2 landscapes, and will go beyond that, producing an abundance of SCFAs & vitamins, thus benefiting the host in several ways.
From improved nutrient absorption, gut motility, evacuations, to-
Neurogenesis, less body fat, enhanced: focus, emotional control, athleticism, exercise results, sleep quality, mitochondria, immune system... and much more.
So, a healthy gut is characterized by an abundance of diverse strains of beneficial bacteria...
While an unhealthy gut?
So, a healthy gut is characterized by an abundance of diverse strains of beneficial bacteria...
While an unhealthy gut?
Is characterized by "good" bacteria/"bad" bacteria imbalance, favoring the latter. This is known as Gut Dysbiosis.
And as aforementioned,
All disease begins there, in the dysbiotic gut
Diabetes, Alzheimer, Autism, Allergies, Cardiovascular Disease, Anxiety, Fatty Liver, IBS...
And as aforementioned,
All disease begins there, in the dysbiotic gut
Diabetes, Alzheimer, Autism, Allergies, Cardiovascular Disease, Anxiety, Fatty Liver, IBS...
But how can these bacteria drive so many diseases?
How can gut dysbiosis be behind health issues that are so common nowadays, like anxiety or obesity?
Surely intestinal toxins don't go & wreck havoc on every organ...
Right?
HAHAHAHAHAHHAHAHAHAHAHAHAHHAHAHAHA, bro look...
How can gut dysbiosis be behind health issues that are so common nowadays, like anxiety or obesity?
Surely intestinal toxins don't go & wreck havoc on every organ...
Right?
HAHAHAHAHAHHAHAHAHAHAHAHAHHAHAHAHA, bro look...
Thanks to gut dysbiosis, the production of:
- Intestinal Alkaline Phosphatase
- SCFAs
- Mucous gel layer
- Antimicrobial peptides
Gets ABOLISHED. Thus, the 4 layers of the intestinal barrier are WEAKENED.
This leads us to the Protective & Structural roles of the microbiome:
- Intestinal Alkaline Phosphatase
- SCFAs
- Mucous gel layer
- Antimicrobial peptides
Gets ABOLISHED. Thus, the 4 layers of the intestinal barrier are WEAKENED.
This leads us to the Protective & Structural roles of the microbiome:
"Protective" refers to how our gut prevents pathogen infection through using the 4 "Structural" layers of the intestinal barrier as a defense, to impede pathogens from colonizing the gut and entering the bloodstream.
Gut Dysbiosis disrupts these 4 layers of defense:
Gut Dysbiosis disrupts these 4 layers of defense:
So, Gut Dysbiosis OBLITERATES these 4 layers.
In consequence, the intestinal barrier starts to become PERMEABLE.
What couldn't go through before, goes through now.
Bacteria, pathogens, PAMPs are reaching the bloodstream now. We call this a Leaky Gut. Its such a bad sign...
In consequence, the intestinal barrier starts to become PERMEABLE.
What couldn't go through before, goes through now.
Bacteria, pathogens, PAMPs are reaching the bloodstream now. We call this a Leaky Gut. Its such a bad sign...
This is intestinal/local inflammation, which will progress into IBS, and if not managed, even Colorectal Cancer
But it doesn’t stops there...
As the “intestinal leakage” will create Systemic Inflammation, and drive disease progression. THIS is the root cause.
You see…
But it doesn’t stops there...
As the “intestinal leakage” will create Systemic Inflammation, and drive disease progression. THIS is the root cause.
You see…
The PAMP we reviewed before, Lipopolysaccharide (LPS - found in the outer membrane of bad bacteria)...
Is one of the first molecules that gets into the bloodstream, and increases inflammation as soon as it does this.
It's one of the most...
Is one of the first molecules that gets into the bloodstream, and increases inflammation as soon as it does this.
It's one of the most...
Powerful immunostimulants in nature. A 100 FOLD decrease in LPS toxicity is NEEDED to make it inactive. Think about that.
Now, LPS binds to the TLR4 receptor of immune cells to elicit the inflammatory response - activating a signaling cascade via MyD88 which results in...
Now, LPS binds to the TLR4 receptor of immune cells to elicit the inflammatory response - activating a signaling cascade via MyD88 which results in...
NF-κB activation, increasing inflammatory cytokines transcription (thus release) such as TNFα, IL-1β, IL-6, and secretion of nitric oxide & eicosanoids.
This, in a HEALTHY, nourished body should terminate the infection.
But breh this body has gut fucking dysbiosis LMAOO!!!!
This, in a HEALTHY, nourished body should terminate the infection.
But breh this body has gut fucking dysbiosis LMAOO!!!!
The immune system doesn’t has the nutrients (Magnesium, Vit. D, C, Zinc) & molecules (melatonin, GSH, GPx) it needs to control their inflammatory response.
Hence, they’ll go into an "inflammatory frenzy" mode, creating excess Inflammation that just gets diminishing results.
Hence, they’ll go into an "inflammatory frenzy" mode, creating excess Inflammation that just gets diminishing results.
And let's remember that these effects were only caused by LPS presence in the bloodstream.
Oh boy Im glad LPS can't reach other organs.
Haha just imagine if LPS could do that
Wouldn't it be so HECKIN funny guys
haha
buckle up bros
Oh boy Im glad LPS can't reach other organs.
Haha just imagine if LPS could do that
Wouldn't it be so HECKIN funny guys
haha
buckle up bros
For LPS to "travel" through your body, to get to the bloodstream in first place,
It needs to be transported by lipoproteins (these can move lipids through water) such as HDL, but mainly via Chylomicrons (CMs). These lipoproteins transport lipids all throughout the body...
It needs to be transported by lipoproteins (these can move lipids through water) such as HDL, but mainly via Chylomicrons (CMs). These lipoproteins transport lipids all throughout the body...
Distributing exogenous and endogenous lipids (fatty acids, fat-soluble vitamins, cholesterol and yes even LPS - WHEN there’s Gut Dysbiosis)
You know where I'm going with this.
As CMs move LPS, your organs start suffering from LPS infiltration. But,
How can LPS affect them?
You know where I'm going with this.
As CMs move LPS, your organs start suffering from LPS infiltration. But,
How can LPS affect them?
🍔 ADIPOSE TISSUE (AT)
Since the AT is where lipids are stored, it's one of Lipoproteins' favorite touristic site. Thus, a large amount of LPS will get here… and once it does?
Activates TLR4. In the AT, this induces...
Insulin Resistance.
Since the AT is where lipids are stored, it's one of Lipoproteins' favorite touristic site. Thus, a large amount of LPS will get here… and once it does?
Activates TLR4. In the AT, this induces...
Insulin Resistance.
Funerino reminderino: Insulin allows glucose to enter the cells yeah but d’you know what intracellular mechanisms take place for this to happen?
Insulin effects are mediated by IRS-1, its phosphorylation in its Tyrosine residues allows IRS-1 to send a signaling cascade that pre-
Insulin effects are mediated by IRS-1, its phosphorylation in its Tyrosine residues allows IRS-1 to send a signaling cascade that pre-
-pares the cell to receive glucose (pic below).
HowFUCKINGever
TLR4 activation (by LPS) phosphorylates IRS-1 in Serine residues instead, cuz TLR4 activated JNK, which is needed to initiate inflammatory responses, Oh no! 😨
okay but what the fuck does this means
HowFUCKINGever
TLR4 activation (by LPS) phosphorylates IRS-1 in Serine residues instead, cuz TLR4 activated JNK, which is needed to initiate inflammatory responses, Oh no! 😨
okay but what the fuck does this means
you see IRS-1 needs tyrosine phosphorylation - this allows it to attract & activate the next molecule in the pathway, PI-3K
now IRS-1 can't do this (shoutout to LPSbrah 🥶)
and da insulin pathway 💯 can't achieve its objective
This establishes Insulin Resistance (IR) in the AT
now IRS-1 can't do this (shoutout to LPSbrah 🥶)
and da insulin pathway 💯 can't achieve its objective
This establishes Insulin Resistance (IR) in the AT
You don't want this at ALL...
IR in the AT imbalances AT's Import/Export of lipids, thus,
A YUGE amount of Free Fatty Acids (FFAs) is released into the bloodstream when they're NOT needed (for ex: FFA release during exercise is good; more fuel).
Stimulating fat accumulation...
IR in the AT imbalances AT's Import/Export of lipids, thus,
A YUGE amount of Free Fatty Acids (FFAs) is released into the bloodstream when they're NOT needed (for ex: FFA release during exercise is good; more fuel).
Stimulating fat accumulation...
In other organs. Fatty muscle, fatty heart, fatty liver, fatty pancreas… fatty dick LMAOXDDXDX!!!
The consequences of this are egregiously appalling. Fat in organs inflames them, this creates scarring, impeding those organs from working correctly, their failure is inevitable.
The consequences of this are egregiously appalling. Fat in organs inflames them, this creates scarring, impeding those organs from working correctly, their failure is inevitable.
You don’t actually need to be fat to go through this.
You only need to stop taking care of your gut health.
You only need to stop taking care of your gut health.
LPS also stimulates M1 & M2 Macrophages in the AT (ATMs). M1 removes dead fat cells (cause of death: they literally got so fat that received oxygen didn't suffice lmao)
And M2 cleans, fixes & repairs AT injuries caused by M1 macrophages (collateral damage). CLEAN IT UP, JANNY!
And M2 cleans, fixes & repairs AT injuries caused by M1 macrophages (collateral damage). CLEAN IT UP, JANNY!
NORMALLY M1 & M2 are balanced. M1 fights and M2 repairs, to keep M1’s shit in place.
But you guessed it, LPS fucks up this balance; favoring the M1 macrophages.
After all LPS also triggers MORE recruitment of Macrophages to the adipose tissue LMAO srsly wtf is lps's problem??
But you guessed it, LPS fucks up this balance; favoring the M1 macrophages.
After all LPS also triggers MORE recruitment of Macrophages to the adipose tissue LMAO srsly wtf is lps's problem??
The implications of this are simple:
Way more inflammation in the adipose tissue. Excacerbating the Adipo-IR, thus everything that comes along with it and accelerating the arrival to Metabolic Syndrome Headquarters.
Now,
Way more inflammation in the adipose tissue. Excacerbating the Adipo-IR, thus everything that comes along with it and accelerating the arrival to Metabolic Syndrome Headquarters.
Now,
🧬 THE LIVER
The connection between Gut Dysbiosis & Liver Disease is clear:
Patients with ANY form of Non Alcoholic Fatty Liver (NAFLD), show a 40-50% increase in both LPS & Zonulin levels, in comparison to fellow healthy patients. Dozens of papers show this.
But why?
The connection between Gut Dysbiosis & Liver Disease is clear:
Patients with ANY form of Non Alcoholic Fatty Liver (NAFLD), show a 40-50% increase in both LPS & Zonulin levels, in comparison to fellow healthy patients. Dozens of papers show this.
But why?
So if LPS infiltration leads to Insulin Resistance, Fatty Organs & overall inflammation, this’ll inevitably reach the liver, and end in NAFLD. You see...
Insulin Resistance & Inflammation, thanks to le cringe american diet (CAD), are critical events for NAFLD onset & progression
Insulin Resistance & Inflammation, thanks to le cringe american diet (CAD), are critical events for NAFLD onset & progression
In fact, both conditions are the “first hits” that throws the liver into the first steps of getting le not so epic Liver Disease,
After all +60% of Obese & T2D patients have NAFLD, sad!!
The problem with these conditions is that it creates vicious cycle:
After all +60% of Obese & T2D patients have NAFLD, sad!!
The problem with these conditions is that it creates vicious cycle:
1. LPS infiltrates to Liver & AT; inflammation!
2. Liver inflammation = impaired Bile Production & detoxification due to poor glutathione & cofactors’ status
3. Poor Bile status = gut dysbiosis, as bile is antimicrobial and cleans bad bacteria.
4. Dysbiosis = LPS translocation
2. Liver inflammation = impaired Bile Production & detoxification due to poor glutathione & cofactors’ status
3. Poor Bile status = gut dysbiosis, as bile is antimicrobial and cleans bad bacteria.
4. Dysbiosis = LPS translocation
5. Liver gets MORE inflamed, overloaded with LPS; can't detoxify it
6. More gut dysbiosis baby cmon I mean oh no!😔
But that's ONLY the indirect way of how LPS fucks up the liver lmao
>it gets worse
6. More gut dysbiosis baby cmon I mean oh no!😔
But that's ONLY the indirect way of how LPS fucks up the liver lmao
>it gets worse
Excess LPS arriving from the portal vein activates Liver's Resident Macrophages (Kupffer Cells/KCs) & Hepatic Stellate Cells (HSCs) via TLR4
KCs are in charge of removing LPS-bacteria, HSCs promotes an inflammatory environment in the liver via upregulating inflammatory pathways
KCs are in charge of removing LPS-bacteria, HSCs promotes an inflammatory environment in the liver via upregulating inflammatory pathways
If not stopped, overtime, this “LPS assault” will damage the liver enough to classify it in the very first stages of NAFLD. After all, HSCs would release lots of TGF-ß1.
the FUCK is that?
the FUCK is that?
Because we of course trust the experts at Alejandro AD headquarters, let me cite this study:
“No cap y’all we stg All listed factors (inflammatory cytokines & processes upregulated by KCs & HSCs) play a hella role in fibrogenesis; but da release of TGF-ß1 is deadass the key
“No cap y’all we stg All listed factors (inflammatory cytokines & processes upregulated by KCs & HSCs) play a hella role in fibrogenesis; but da release of TGF-ß1 is deadass the key
event in the pathogenesis of mf fibrosis fr fr. All factors are str8 complimentary to each other bruh and synergistically contribute to the development of fibrosis no cap. This shit is not bussin fr fam”
So TGF-B1 is what drives that "first hit" huh. Epic diagrams incoming:
So TGF-B1 is what drives that "first hit" huh. Epic diagrams incoming:
LPS infiltration in the Liver will also cause Hepatic Insulin Resistance, which significantly increases Hepatic Lipogenesis AND impairs Liver’s ability to degrade excess fatty acids, thus slowly building up MORE Liver Fat. Until surprise surprise, fatty liver.
Congrats now you’re on the road to Liver Cancer (unironically). Imagine not cancermaxxing couldn't be me fr fam 🥶
Also the liver & the AT fuck each other up during LPS translocation, creating a vicious cycle. I stg these mfs dumb as fuck bruh fr
Also the liver & the AT fuck each other up during LPS translocation, creating a vicious cycle. I stg these mfs dumb as fuck bruh fr
🧠 THE BRAIN
Most of you know that your mental health is YUGELY dependant on your gut health and that fucked gut = fucked mind.
But, why?
Lets get straight to the point:
LPS overstimulates Microglia. Thus, they release lots of ROS, Glutamate & Inflammatory Cytokines.
Most of you know that your mental health is YUGELY dependant on your gut health and that fucked gut = fucked mind.
But, why?
Lets get straight to the point:
LPS overstimulates Microglia. Thus, they release lots of ROS, Glutamate & Inflammatory Cytokines.
60th TWEET LETS GO!!!
In the brain, LPS overstimulates immune cells called “Microglia”. These are the main and first forms of immune defense, although they have other crucial roles:
In the brain, LPS overstimulates immune cells called “Microglia”. These are the main and first forms of immune defense, although they have other crucial roles:
If NMDA’s Glutamate overstimulation is sustained long enough, neurotoxicity will take place - where neurons get overexcited and eventually die.
After all, Glutamate triggers Calcium entry to your neurons, a mineral with a positive charge, thus, it increases a neuron's electrical charge, it excites it.
Homage CK Eternity & Grimhood
Homage CK Eternity & Grimhood
The short term consequences of this overstimulation are:
- ANXIETY
- Headaches
- Brain Fog
- Insomnia
The long term consequences are Neurological diseases. Alzheimer, Parkinson, Depression.
- ANXIETY
- Headaches
- Brain Fog
- Insomnia
The long term consequences are Neurological diseases. Alzheimer, Parkinson, Depression.
To end with this final section, this is a VERY basic explanation of Dysbiosis-Neurodegeneration connection. The biochemical pathways, molecules and more aspects affected by LPS, I consider them to be complex enough to confuse a beginner.
Plus this masterpiece of a thread is 64-
Plus this masterpiece of a thread is 64-
Tweets long already lmao
For my advanced health freaks, I will explain the Gut-Brain Axis deeper in the next patreon posts, and in following threads/tweets.
For my advanced health freaks, I will explain the Gut-Brain Axis deeper in the next patreon posts, and in following threads/tweets.
CONCLUSION
Most of you that are reading this won’t be & aren’t so unhealthy that your liver, brain & AT are found close to the point of no return (more like, the point of “extreme effort will be needed to return”). This is exactly why you shouldn’t relax with diet & lifestyles.
Most of you that are reading this won’t be & aren’t so unhealthy that your liver, brain & AT are found close to the point of no return (more like, the point of “extreme effort will be needed to return”). This is exactly why you shouldn’t relax with diet & lifestyles.
Understand that right now, if you take the decision to improve and fix your nutrition, your health habits, your gut, the rewards will be glorious.
Superior cognitive & athletic performance, accelerated recovery, increased libido, motivation, focus, enhanced immune system...
Superior cognitive & athletic performance, accelerated recovery, increased libido, motivation, focus, enhanced immune system...
If you want to achieve those goals with ease, and sustain them. DM me "coaching", I'd love to work with you to create your healthiest self - free of dysbiosis & full of energy.
This thread was just an introduction to beginners on why all common diseases nowadays (obesity, neurodegeneration, fatty liver, etc.) come from the gut. Upcoming posts will go deeper.
Also, fix your gut here:
Also, fix your gut here:
retweet this NOW fellow kefir enjoyers
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