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I have to refresh my memory from time to time about the relationship between creatine (Cr), creatine kinase (CK) and creatinine. As a hematologist, I traffic in all the above (e.g. differentiating rhabdo from hemolysis, diagnosing anemia of CKD), but only peripherally.
I have to refresh my memory from time to time about the relationship between creatine (Cr), creatine kinase (CK) and creatinine. As a hematologist, I traffic in all the above (e.g. differentiating rhabdo from hemolysis, diagnosing anemia of CKD), but only peripherally.
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Here is my take (see graphic):
1. Creatine is an amino acid naturally produced in the human body from the amino acids glycine and arginine
2. CK converts Cr to PCr, which may then generate ATP at times of need, producing a ready source of energy, especially in muscle
Here is my take (see graphic):
1. Creatine is an amino acid naturally produced in the human body from the amino acids glycine and arginine
2. CK converts Cr to PCr, which may then generate ATP at times of need, producing a ready source of energy, especially in muscle
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3. Creatinine is a byproduct/degradation product of Cr (and to a lesser extent PCr), formed by an irreversible, non-enzymatic process at a constant rate (thus, in proportion to muscle mass)
3. Creatinine is a byproduct/degradation product of Cr (and to a lesser extent PCr), formed by an irreversible, non-enzymatic process at a constant rate (thus, in proportion to muscle mass)
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