How to optimize metabolic health (thread series).
Part 1: Anti-metabolic compounds.
Part 1: Anti-metabolic compounds.
*Standard disclaimer that this does not constitute medical advice*
Metabolism is defined as the whole range of biochemical processes that occur within a living organism and it constitutes the two processes of anabolism (build up) and catabolism (break down).
Metabolism is defined as the whole range of biochemical processes that occur within a living organism and it constitutes the two processes of anabolism (build up) and catabolism (break down).
The term metabolism is referring to the overall chemical reactions that occur in an organism.
So things such as: our digestive system, endocrine system, immune system, methylation track and in general every biological process that happens in our bodies is part of our metabolis
So things such as: our digestive system, endocrine system, immune system, methylation track and in general every biological process that happens in our bodies is part of our metabolis
Now the term metabolic rate is referring to the frequency of the metabolic pathways or the amount of energy that is used by an organism in order to maintain the above processes.
Now pro-metabolic compounds are compounds that support our metabolic health and anti-metabolic
Now pro-metabolic compounds are compounds that support our metabolic health and anti-metabolic
compounds things that harm it.
Let's start with the (main) anti-metabolic compounds:
1) PUFAs
PUFAs directly suppress our metabolism (this is why the meat industry uses PUFAs (it is cheaper to fatten animals with a suppressed metabolism)), deplete antioxidants such vitamin E,
Let's start with the (main) anti-metabolic compounds:
1) PUFAs
PUFAs directly suppress our metabolism (this is why the meat industry uses PUFAs (it is cheaper to fatten animals with a suppressed metabolism)), deplete antioxidants such vitamin E,
increase estrogen, unbound iron and have a myriad of negative effects on our health.
PUFAs harm the ability of the cells to use glucose by blocking the pyruvate dehydrogenase enzyme that is essential for the use of glucose .
Also palmitic acid, which is a major component of
PUFAs harm the ability of the cells to use glucose by blocking the pyruvate dehydrogenase enzyme that is essential for the use of glucose .
Also palmitic acid, which is a major component of
the cardiolipin, becomes displaced by PUFAs and cancer cells are known to have a high level of unsaturated fats, making unsaturated fats a common driver of cancer in todayโs society.
PUFAs also interact closely with serotonin (PUFAs for example increase the turnover from 5HT
PUFAs also interact closely with serotonin (PUFAs for example increase the turnover from 5HT
into serotonin) and tryptophan, two compounds that are also anti-metabolic.
For more detail and also how to properly detox from PUFAs you can read this guide.
For more detail and also how to properly detox from PUFAs you can read this guide.
2) Heavy metals
Mitochondria are the first target sites for a variety of heavy metals.
They alter mitochondrial membrane permeability and generate increased amounts of reactive oxygen species (ROS) which causes damage to the mitochondrial respiratory chain, oxidative
Mitochondria are the first target sites for a variety of heavy metals.
They alter mitochondrial membrane permeability and generate increased amounts of reactive oxygen species (ROS) which causes damage to the mitochondrial respiratory chain, oxidative
phosphorylation decoupling, ATP synthesis disorders and mitochondrial apoptosis.
For example, chronic mercury exposure results in its accumulation in mitochondria, which causes ultrastructural mitochondrial alterations that depolarize the mitochondrial membrane and
For example, chronic mercury exposure results in its accumulation in mitochondria, which causes ultrastructural mitochondrial alterations that depolarize the mitochondrial membrane and
subsequently reduce ATP production and Ca2+ buffering capacity.
Another example is that mercury and arsenic promote an abnormal regulation of mitophagy(mitophagy has the ability to clear damaged mitochondrial components) and the development of CRS.
Another example is that mercury and arsenic promote an abnormal regulation of mitophagy(mitophagy has the ability to clear damaged mitochondrial components) and the development of CRS.
Properly addressing heavy metals is of course a big topic and this is why i recommend you checking this thread as well in order to avoid misconceptions.
3) Excessive nitric oxide.
Nitric oxide is of course crucial for our health but donโt forget that nitric oxide is a free radical so when in excess, it will create reactive oxygen species through reducing the cellsโ ability to respirate properly.
Nitric oxide is of course crucial for our health but donโt forget that nitric oxide is a free radical so when in excess, it will create reactive oxygen species through reducing the cellsโ ability to respirate properly.
Nitric oxide is the most potent accelerator of the aging process because it directly inhibits the activity of mitochondria.
What promotes nitric oxide excess?
ED supplements and medication, pre workout supplements (reason why a lot of bodybuilders (even natural ones) have
What promotes nitric oxide excess?
ED supplements and medication, pre workout supplements (reason why a lot of bodybuilders (even natural ones) have
xtremely aged faces), not enough sunlight, lack of antioxidants, excessive fasting, not eating sulfurous vegetables (which need to always be eaten slow cooked in animal fats), gut problems and tap water.
So what can you do in order to prevent a nitric oxide excess?
A)Take care of your gut.
B) Address ROS as you read on yesterday's thread.
C) Stop consuming nitric oxide products and pump enhancers.
D) Make sure that you get enough sunlight.
E) Optimize CO2.
A)Take care of your gut.
B) Address ROS as you read on yesterday's thread.
C) Stop consuming nitric oxide products and pump enhancers.
D) Make sure that you get enough sunlight.
E) Optimize CO2.
F) Lower exposure to blue light (crucial).
G) Turmeric (do not consume turmeric if your iron levels are too low or you struggle with low DHT and turmeric should not be cycled (very rarely there is a need to be consumed more than 2 weeks straight).
G) Turmeric (do not consume turmeric if your iron levels are too low or you struggle with low DHT and turmeric should not be cycled (very rarely there is a need to be consumed more than 2 weeks straight).
H) And of course, address excessive estrogen/estrogen dominance.
Which brings us to:
4) Excessive estrogen
Estrogen inhibits pyruvate dehydrogenase and blocks the function of cytochrome oxidase.
Besides this, estrogen create a mirriad of health problems.
Which brings us to:
4) Excessive estrogen
Estrogen inhibits pyruvate dehydrogenase and blocks the function of cytochrome oxidase.
Besides this, estrogen create a mirriad of health problems.
For example estrogen:
1) Block the secretion of thyroxin.
2) Promote the retention of iron (why this is a bad thing and what we can do about it, on the heavy metal detox part of this lesson).
3) Release histamine.
4) Are an antagonist for vitamin E and magnesium.
1) Block the secretion of thyroxin.
2) Promote the retention of iron (why this is a bad thing and what we can do about it, on the heavy metal detox part of this lesson).
3) Release histamine.
4) Are an antagonist for vitamin E and magnesium.
5) Destroy certain areas of the adrenal cortex.
6) Promote the development of tumors.
7) Cause osteoarthritis.
8) Cause infertility and miscarriages.
9) Lower testosterone and progesterone.
10) Cause depression, anxiety and panic disorders.
11) Increase nitric oxide.
6) Promote the development of tumors.
7) Cause osteoarthritis.
8) Cause infertility and miscarriages.
9) Lower testosterone and progesterone.
10) Cause depression, anxiety and panic disorders.
11) Increase nitric oxide.
12) Lower the seizure threshold of nerve cells.
13) Can cause dementia.
14) Were even identified as a carcinogen.
15) Severely age your skin and tendons (many tendinitis in women who experience menopause gets reversed through progesterone).
13) Can cause dementia.
14) Were even identified as a carcinogen.
15) Severely age your skin and tendons (many tendinitis in women who experience menopause gets reversed through progesterone).
16) Cause chronic fatigue (some forms of estrogen harm NAD/NADH).
17) Deplete you of zinc.
Estrogen in the right amount, are of course necessary since nothing in our body is useless.
The problem is that the tissues that need to be stimulated by estrogen, very briefly and not
17) Deplete you of zinc.
Estrogen in the right amount, are of course necessary since nothing in our body is useless.
The problem is that the tissues that need to be stimulated by estrogen, very briefly and not
chronically like in todayโs society.
So avoid phytoestrogens, xenoestrogens, detox from both, up the anti-estrogenic fat soluble vitamins, reduce PUFA consumption, use binders, get sunlight, optimize andorgens and address NO.
This will be a good start.
So avoid phytoestrogens, xenoestrogens, detox from both, up the anti-estrogenic fat soluble vitamins, reduce PUFA consumption, use binders, get sunlight, optimize andorgens and address NO.
This will be a good start.
Number 5: Stress hormones
Stress has been known to cause breakage of the nuclear chromosomes and damage mitochondrial genes.
Stress will directly suppress our metabolism, severely lower testosterone, cause hair loss, increase serotonin, estrogen, prolactin and damage our gut.
Stress has been known to cause breakage of the nuclear chromosomes and damage mitochondrial genes.
Stress will directly suppress our metabolism, severely lower testosterone, cause hair loss, increase serotonin, estrogen, prolactin and damage our gut.
Stress will of course raise cortisol and adrenaline which lead to excessive metabolism of protective hormones such as progesterone through (partly) the progesterone steal.
Stress inevitably leads to a deficiency of all of the steroid protective hormones.
Stress inevitably leads to a deficiency of all of the steroid protective hormones.
Avoiding alcohol, getting plenty of sleep, not fasting extensively (daily fasting for more than 12-14 hours), plenty of grounding, optimize GABA, minimize exposure to nnEMF, balance the amino acid profile of your diet, do not follow extreme diets such as carnivore omad and
make sure that you do not over-exercise(*) in order to not trigger the production of too much lactic acid (if you live your workouts burn out, you overdid it), making sure that you get enough magnesium, bioavailable protein, zinc and glycine will all be crucial in order to
restore metabolic health by lowering stress hormones.
Glycine modulates the cytokines that are involved in many inflammatory diseases and will also help you manage NO production.
(*)The fatigue produced by over training is produced by a tryptophan and serotonin overload both
Glycine modulates the cytokines that are involved in many inflammatory diseases and will also help you manage NO production.
(*)The fatigue produced by over training is produced by a tryptophan and serotonin overload both
of which are anti-metabolic. Itโs better to break your workouts into more sessions with less volume, than it is to burn yourself out.
6)Excessive lactic acid
Lactic acid reduces oxidative production of energy (it inhibits pyruvate dehydrogenase) and is involved in the
6)Excessive lactic acid
Lactic acid reduces oxidative production of energy (it inhibits pyruvate dehydrogenase) and is involved in the
degradation of mitochondria.
In fact, lactic acid can be so anti-metabolic that it can be considered as one of the main drivers of cancer since high lactate generation is commonly seen in cancer cells and tumors.
Lactic acid also has opposite effects to the protective CO2 and
In fact, lactic acid can be so anti-metabolic that it can be considered as one of the main drivers of cancer since high lactate generation is commonly seen in cancer cells and tumors.
Lactic acid also has opposite effects to the protective CO2 and
lactic acid buildup can even trigger seizures, heart failure (excessive lactic acid ages the heart and this is one reason why athletes experience heart problems (anabolic steroids such as HGH being another one)) it leads to calcified tissues and of course harm the liver and
kidneys as well.
So:
Step 1: Increase CO2 as will be demonstrated in the next module since increasing C02 limits the formation of lactic acid due to its opposing effects.
Step 2: Use a meal of seasonal fruit, bioavailable protein, thiamine and coconut oil as a pre workout meal
So:
Step 1: Increase CO2 as will be demonstrated in the next module since increasing C02 limits the formation of lactic acid due to its opposing effects.
Step 2: Use a meal of seasonal fruit, bioavailable protein, thiamine and coconut oil as a pre workout meal
and coconut water or sparkling water that is naturally carbonated intra workout.
This meal is extremely effective for preventing lactic acid build up and improving your performance.
You will notice the benefits from the first session (do not skip the coconut oil).
This meal is extremely effective for preventing lactic acid build up and improving your performance.
You will notice the benefits from the first session (do not skip the coconut oil).
Thiamine prevents lactic acid build up (*) and coconut oil contains palmitic acid which activates a respiratory enzyme which suppresses the formation of lactic acid.
(*) Taking thiamine is a treatment for lactic acidosis but also generally helps to reduce lactic acid
(*) Taking thiamine is a treatment for lactic acidosis but also generally helps to reduce lactic acid
production when the individual is under stress and promotes normal cellular respiration
Step 3: Optimize thyroid performance (full protocol in this lesson).
Step 4: Short term biotin supplementation.
Excess lactic acid can be โtreatedโ by poisoning glycolysis by using
Step 3: Optimize thyroid performance (full protocol in this lesson).
Step 4: Short term biotin supplementation.
Excess lactic acid can be โtreatedโ by poisoning glycolysis by using
dichloroacetic acid and increasing the oxidation of glucose.
Well, things such as thiamine, biotin and thyroid, increase the oxidation of glucose as well but way more safer and more effectively.
This is why a B vitamin deficiency is directly linked to lactic acidosis.
Well, things such as thiamine, biotin and thyroid, increase the oxidation of glucose as well but way more safer and more effectively.
This is why a B vitamin deficiency is directly linked to lactic acidosis.
Step 5: No fermented foods (this includes beer).
Some beers purposely contain lactic acid such as the Belgian lambics.
Bacterial lactic acid is way more toxic than the type that we form under conditions such as training. So avoid foods such as kimchi, yogurt and sourdough.
Some beers purposely contain lactic acid such as the Belgian lambics.
Bacterial lactic acid is way more toxic than the type that we form under conditions such as training. So avoid foods such as kimchi, yogurt and sourdough.
Done.
Part 2 will drop tomorrow to stay tuned for that.
If you enjoyed this thread drop a like to the first tweet.
P.S: I also started reserving the next client spots so if you want one drop a DM.
Part 2 will drop tomorrow to stay tuned for that.
If you enjoyed this thread drop a like to the first tweet.
P.S: I also started reserving the next client spots so if you want one drop a DM.
Pregnenolone steal*
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