Worried about fertility?
Myo-Inositol and other inositols, a pro-fertility supplement that may also aid with autoimmune diseases, thyroid function, cancer and diabetes.Β
A THREAD
π§΅
Myo-Inositol and other inositols, a pro-fertility supplement that may also aid with autoimmune diseases, thyroid function, cancer and diabetes.Β
A THREAD
π§΅
Inositols are types of sugar alcohols that make up a component of the outer membrane of cells and thus help control what goes in and out of them.
They also act as second messengers involved in the binding of extracellular signalling molecules to receptors located on the cell surface or inside the cell that trigger events inside the cell.
There are various forms of inositols, of which myo-inositol (MI) is the most common and found in a variety of food products, with the greatest amounts of myo-inositol being present in fruits, beans, grains, and nuts.
Other than in food, MI is also produced in the human body from glucose and is present in all living cells as other forms such as phosphatidylinositol, D-chiro-inositol (DCI) and phytic acid (also known as Inositol hexaphosphate or IP6).
Our gut microbiome, with its bacterial phytases and phosphatases, is primarily responsible for digesting dietary IP6 in the body and for releasing myo-inositol and phosphate.
Though not classed as an essential nutrient because it is formed from glucose, it is very likely that a great majority of us are living with inositol deficiency and imbalance.
Firstly, caffeine (particularly coffee) increases the need for MI. MI also concentrates in tissues such as kidneys, brain, and blood cells, which are typically no longer consumed by us.
MI requirements rise with age, usage of antibiotics, consumption of sugar and refined carbohydrates, salt deficiency, insulin resistance, and both type I and type II diabetes.
Plus, the biosynthesis of myo-inositol requires NAD+ and magnesium. Thus, a deficiency in either may lead to a deficiency in MI.
Low MI levels have been seen in liver disease, stroke, certain thyroid diseases, lymphoma, and various other diseases. The presence of free-floating MI in the blood seems to deter the formation of fatty liver, and so it makes sense why MI deficiency can cause fatty liver.
Elevated blood sugar levels (via insulin) decrease the absorption and biosynthesis of MI and increase its degradation and excretion via urine. MI levels are higher in tissues that use large amounts of glucose, such as the brain, heart, and ovaries.
MI supplementation, especially in those with diabetes, has been shown to improve insulin sensitivity and is speculated to improve diabetes-related diseases such as eye and nerve damage.
Animal studies have shown that the administration of MI and IP6 independently has anticancer effects, and a combination of IP6 and MI has been shown to be significantly better at fighting certain cancers than either of the two acting alone.
pubmed.ncbi.nlm.nih.gov
pubmed.ncbi.nlm.nih.gov
Supplementing MI and/or DCI in women with PCOS has shown to improve insulin resistance, helped normalised menstrual periods, improve egg maturation, pregnancy rates, delivery rates and fertility hormone profiles.
Regardless of whether someone has PCOS or not, inositol imbalance has been postulated to lead to reduced fertility or pregnancy complications, thus, its administration may be useful in the prevention and treatment of several pregnancy-related pathologies.
ncbi.nlm.nih.gov
ncbi.nlm.nih.gov
Clinical evidence has demonstrated that the 40:1 ratio between MI and DCI is the optimal combination to restore ovulation in PCOS women.
hindawi.com
hindawi.com
Inositol in men with fertility issues is promising too. In one study of men with reduced sperm motility and metabolic syndrome, the use of a supplement containing MI and antioxidants resulted in increased T levels and improved semen characteristics.
ncbi.nlm.nih.gov
ncbi.nlm.nih.gov
In another study, MI improved sperm motility and improved pregnancy rates.
ncbi.nlm.nih.gov
ncbi.nlm.nih.gov
With regards to immunity, mice with deletions of genes encoding members of the inositol signalling pathway cascade showed defects in NK cell expression and function.
Disruption of inositol pathways in other animal studies lead to autoimmunity.
pubmed.ncbi.nlm.nih.gov
Disruption of inositol pathways in other animal studies lead to autoimmunity.
pubmed.ncbi.nlm.nih.gov
MI seems to be vital for the proper running of the thyroid gland, and in one study, people with autoimmune thyroid disease were given MI and selenium, resulting in lower auto-immune thyroid antibodies, enhanced thyroid hormones, and better wellbeing.
ncbi.nlm.nih.gov
ncbi.nlm.nih.gov
There has been no research so far studying the use of inositol and COVID-19 outcomes, but one scientific review did hypothesise that inositol and vit D may naturally protect human reproduction and women undergoing assisted reproduction from COVID-19 risk.
ncbi.nlm.nih.gov
ncbi.nlm.nih.gov
Inositols should be used alongside general lifestyle changes to aid fertility. But whether or not they may help with jab-related infertility is another question.
Regardless, with a lot of the population deficient in MI and at risk of infertility, it may be wise looking into it.
Regardless, with a lot of the population deficient in MI and at risk of infertility, it may be wise looking into it.
If youβre interested in learning about MI and other supplements that may help post-jab with supported references and dosages, and wish to support me in continuing to help you, click on the link in the description below.Β
callingouttheshots.xyz
callingouttheshots.xyz
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