The many benefits of fasting.
The science and art of not eating.
A THREAD π§΅
The science and art of not eating.
A THREAD π§΅
During yesterday's Twitter Space, fasting was brought up as a way to reduce inflammation and possibly help cells damaged by spike proteins.
I believe fasting may be a great for people in this regard.
So let's learn all about it.
I believe fasting may be a great for people in this regard.
So let's learn all about it.
In a world where food consumption is endlessly promoted, fasting may seem not only a little strange but also counter-cultural.
Though abstinence from eating and sometimes drinking is common practice in various religions, its history in modern medicine has been a turbulent one.
Though abstinence from eating and sometimes drinking is common practice in various religions, its history in modern medicine has been a turbulent one.
Fasting has a history of being labelled as a fad diet, a path to "digestive ruin," and those who promote it as faddists and quacks.
But emerging scientific evidence is beginning to paint a very different picture.
archive.org
But emerging scientific evidence is beginning to paint a very different picture.
archive.org
First, what's the difference between fasting and starvation?
Fasting is defined as βabstinence from food or drink or both for health, ritualistic, religious, or ethical purposes. The abstention may be complete or partial, lengthy, of short duration, or intermittent.β
Whilst starvation is defined as, βwidespread or generalized atrophy (wasting away) of body tissues either because food is unavailable or because it cannot be taken in or properly absorbed.β
In other words, fasting is a short period of time of food or water abstinence that YOU have control over, in our case, used for biological optimisation.
Intermittent fasting (IF) is an increasingly popular dietary practice that consists of regular alternating periods of unrestricted dietary consumption and abstinence from food intake.
One group of researchers has defined IF as the umbrella term to mean
βeating patterns in which individuals go extended time periods (e.g., 16β48 h) with little or no energy intake, with intervening periods of normal food intake, on a recurring basis.
ncbi.nlm.nih.gov
βeating patterns in which individuals go extended time periods (e.g., 16β48 h) with little or no energy intake, with intervening periods of normal food intake, on a recurring basis.
ncbi.nlm.nih.gov
Time-restricted eating (TRE) is a type of IF with continuous short periods of fasting and food consumption typically within an 8- to 10-hour window period.
Other versions of IF include reducing food consumption over 2-3 days per week or on alternate days.
Other versions of IF include reducing food consumption over 2-3 days per week or on alternate days.
The majority of research looking into IF has focused on weight loss, and the results here look very promising.
IF has also been shown to improve markers of metabolic health and insulin sensitivity.
ncbi.nlm.nih.gov
IF has also been shown to improve markers of metabolic health and insulin sensitivity.
ncbi.nlm.nih.gov
Many people who practise IF claim that going without food for extended periods of time has positive effects on their psychological and spiritual well-being.
And research has shown the fasting is related to
- extension of life expectancy
- lowering the production of ROS
- improving inflammatory marker profiles
- being associated with DNA repair and immune system optimisation.
ncbi.nlm.nih.gov
- extension of life expectancy
- lowering the production of ROS
- improving inflammatory marker profiles
- being associated with DNA repair and immune system optimisation.
ncbi.nlm.nih.gov
The ketogenic diet (KD) is commonly also referred to as a βfast-mimickingβ diet as both KD and fasting use fats, which turn into ketone bodies, for energy.
Ketones bodies have a wide range of physiological benefits, that I will get into in another thread.
Ketones bodies have a wide range of physiological benefits, that I will get into in another thread.
Fasting comes with additional benefits:
1. Activating autophagy
Autophagy is a process whereby the body degrades unnecessary or dysfunctional cellular components for energy.
1. Activating autophagy
Autophagy is a process whereby the body degrades unnecessary or dysfunctional cellular components for energy.
Autophagy is a potential therapeutic target for a diverse range of diseases, including metabolic conditions, neurodegenerative diseases, cancers, infectious diseases, prion disease, and has even been shown to reverse an advanced form of cardiomyopathy.
ahajournals.org
ahajournals.org
2. Activating sirtuins
Sirtuins are a family of proteins that regulate cellular health, promote DNA repair, and promote longevity.
By activating sirtuins, fasting can aid in DNA repair and protection and somewhat ameliorate the effects of ageing.
Sirtuins are a family of proteins that regulate cellular health, promote DNA repair, and promote longevity.
By activating sirtuins, fasting can aid in DNA repair and protection and somewhat ameliorate the effects of ageing.
Before you carry on, I'd like to let you know that if you'd like to know more about fasting and how it may help with jab injuries, then it's all in one place, the book ππΎ
callingouttheshots.xyz
callingouttheshots.xyz
3. Reduced systemic inflammation
The Oxidative Stress Hypothesis postulates that free-floating radicals are reduced during fasting.
This is thought to happen due to lower mitochondrial energy production, lowering the body's oxidative stress.
ncbi.nlm.nih.gov
The Oxidative Stress Hypothesis postulates that free-floating radicals are reduced during fasting.
This is thought to happen due to lower mitochondrial energy production, lowering the body's oxidative stress.
ncbi.nlm.nih.gov
4. Iron-removing
Too much iron is not good. A variety of diseases, including fungal infections, can flourish in the presence of too much iron.
Iron overload is also linked to inflammation, and this has been noted to occur when red blood cells are destroyed by the spike protein.
Too much iron is not good. A variety of diseases, including fungal infections, can flourish in the presence of too much iron.
Iron overload is also linked to inflammation, and this has been noted to occur when red blood cells are destroyed by the spike protein.
Ferritin, an iron storage and buffering protein, is an indirect marker of the total amount of iron stored in the body.
It has been noted that those with severe COVID-19 disease have extremely high ferritin levels.
ncbi.nlm.nih.gov
It has been noted that those with severe COVID-19 disease have extremely high ferritin levels.
ncbi.nlm.nih.gov
Fasting has been shown to both reduce levels of iron and ferritin concentrations as well as decrease the expression of genes associated with iron storage and export and increase the expression of genes involved in iron acquisition.
pubmed.ncbi.nlm.nih.gov
pubmed.ncbi.nlm.nih.gov
Interestingly, turmeric, the yellow spice, can also reduce iron levels.
5. Changes in P-gp expression
Permeability-glycoprotein (P-gp) is a cell transporter that plays a major role in pumping many bodily substances and foreign material out of cells. P-gp is critical for drug detoxification.
pubmed.ncbi.nlm.nih.gov
Permeability-glycoprotein (P-gp) is a cell transporter that plays a major role in pumping many bodily substances and foreign material out of cells. P-gp is critical for drug detoxification.
pubmed.ncbi.nlm.nih.gov
P-gp has also been shown to transport amyloid-Ξ², a protein that is associated with Alzheimerβs disease.
Low levels of P-gp in brain capillaries are inversely related to amyloid- deposition in the brain.
ncbi.nlm.nih.gov
Low levels of P-gp in brain capillaries are inversely related to amyloid- deposition in the brain.
ncbi.nlm.nih.gov
12 to 24-hour fasting has been shown to increase the liver levels of P-gp in male mice.
pubmed.ncbi.nlm.nih.gov
pubmed.ncbi.nlm.nih.gov
In one paper it was noted that proper feeding patterns might up-regulate toxin transporters in healthy tissues, thus reducing the side effects of chemotherapy (and theoretically, other toxin build-up).
pubmed.ncbi.nlm.nih.gov
pubmed.ncbi.nlm.nih.gov
6. Boosting immunity
Cycles of fasting have shown to reduce autoimmunity, activate lymphocyte-dependent killing of cancer cells, promote stem cell activation, regenerate immune cells and reverse immunosuppression, ameliorate pathology in various mouse autoimmunity models...
Cycles of fasting have shown to reduce autoimmunity, activate lymphocyte-dependent killing of cancer cells, promote stem cell activation, regenerate immune cells and reverse immunosuppression, ameliorate pathology in various mouse autoimmunity models...
...trigger T cells to move to the bone marrow, promote survival and enhanced protective function, and enhance memory T cell development.
pubmed.ncbi.nlm.nih.gov
pubmed.ncbi.nlm.nih.gov
One study showed that a 72-hour fast not only protected against chemotherapy-related immune system damage but also induced immune system regeneration, shifting stem cells from a dormant state to a state of self-renewal.
cell.com
cell.com
Programmed cell death protein 1 (PD-1) is a protein found on the surface of T and B cells that helps prevent autoimmune diseases by down-regulating the immune system and promoting self-tolerance by suppressing T cell inflammatory activity.
PD-1 is also associated with T-cell exhaustion or dysfunction in many clinical settings.
But ketone production has shown to study noted to reduce PD-1 expression on T cells in vitro and in vivo.
nature.com
But ketone production has shown to study noted to reduce PD-1 expression on T cells in vitro and in vivo.
nature.com
Real-life evidence seems to highlight the benefits of IF too. One prospective study showed that, βRoutine periodic fasting was associated with a lower risk of hospitalisation or mortality in patients with COVID-19.β
nutrition.bmj.com
nutrition.bmj.com
Timing and what is eaten before and after a fast seem to be as important as the fast itself.
Water-only fasting cycles, for example, have been shown to only promote limited changes in the gut microbiota and result in increased gut leakiness in mice.
pubmed.ncbi.nlm.nih.gov
Water-only fasting cycles, for example, have been shown to only promote limited changes in the gut microbiota and result in increased gut leakiness in mice.
pubmed.ncbi.nlm.nih.gov
As you can agree, fasting has far-reaching benefits for our health and immunity. But it must be highlighted again that not everyone will find prolonged fasting easy (especially if you have underlying thyroid issues, for example).
ncbi.nlm.nih.gov
ncbi.nlm.nih.gov
Nor may it be safe for you to undergo fasting (if youβre prone to suffer from low blood sugar levels, for example).
And so I must reiterate: please, for your own safety, seek professional medical advice before thinking of going without food for a prolonged period of time.
And so I must reiterate: please, for your own safety, seek professional medical advice before thinking of going without food for a prolonged period of time.
Loading suggestions...