Understanding POMC
The key to ending the obesity, diabetes, heart disease, neurodegenerative, and cancer crisis
POMC & PEPTIDE THREAD
The key to ending the obesity, diabetes, heart disease, neurodegenerative, and cancer crisis
POMC & PEPTIDE THREAD
Many of us know of Dr. Jack Kruse
He relentlessly beats this drum about understanding POMC, its derivatives, and how they impact human health
I have yet to see a comprehensive breakdown on this
So I said fuck it and wrote the thread myself so that you fully understand
He relentlessly beats this drum about understanding POMC, its derivatives, and how they impact human health
I have yet to see a comprehensive breakdown on this
So I said fuck it and wrote the thread myself so that you fully understand
It’s not easy to piece all this together
Take this thread seriously and learn from it because it comes at the hand of my obsessive tendency
Once you understand this, you’re perspective on health changes forever
Take this thread seriously and learn from it because it comes at the hand of my obsessive tendency
Once you understand this, you’re perspective on health changes forever
What is POMC?
We’re talking about a protein known as proopiomelanocortin (POMC)
It originates from the POMC gene which is located on chromosome 2 in human beings
This one pathway is everything
It explains most of the dysfunction we see as a result of modern living
We’re talking about a protein known as proopiomelanocortin (POMC)
It originates from the POMC gene which is located on chromosome 2 in human beings
This one pathway is everything
It explains most of the dysfunction we see as a result of modern living
What’s special about it?
It’s ancient in origin, conserved over the course of hundreds of millions of years
Mother Nature has crafted this gene to perfection. Expect nothing less of her
As you read more here, you’ll understand why it’s important
It’s ancient in origin, conserved over the course of hundreds of millions of years
Mother Nature has crafted this gene to perfection. Expect nothing less of her
As you read more here, you’ll understand why it’s important
POMC itself is cut (cleaved) into multiple peptide hormones that have an enormous influence on health
These peptides bind to one of several proteins in different regions of the body
This binding triggers signaling pathways that control many important metabolic functions
These peptides bind to one of several proteins in different regions of the body
This binding triggers signaling pathways that control many important metabolic functions
Here’s the juicy part:
POMC is fundamentally married to circadian biology which means that light is everything here
Understanding the difference between healing sunlight and toxic artificial light is crucial
POMC is fundamentally married to circadian biology which means that light is everything here
Understanding the difference between healing sunlight and toxic artificial light is crucial
As I mentioned earlier, POMC is cleaved into a number of peptides
What are these peptides?
Read more
What are these peptides?
Read more
1. LEPTIN
The first on the list is leptin, what most refer to as the satiety hormone
Leptin is a peptide hormone found in fat cells that’s stimulated by POMC neurons which is responsible for
• appetite regulation
• energy expenditure
• fat storage
And more
The first on the list is leptin, what most refer to as the satiety hormone
Leptin is a peptide hormone found in fat cells that’s stimulated by POMC neurons which is responsible for
• appetite regulation
• energy expenditure
• fat storage
And more
Leptin resistance has been referenced a lot recently
In conditions of obesity, this is where the brain becomes less responsive to leptin’s signals
As a result, dysregulation of POMC and other appetite-related pathways occur
In conditions of obesity, this is where the brain becomes less responsive to leptin’s signals
As a result, dysregulation of POMC and other appetite-related pathways occur
2. α-MSH
Alpha-melanocyte stimulating hormone is another peptide made from POMC responsible for creating melanin which is an absolute powerhouse for health
Read more about melanin below
Alpha-melanocyte stimulating hormone is another peptide made from POMC responsible for creating melanin which is an absolute powerhouse for health
Read more about melanin below
3. β-MSH
Beta-melanocyte stimulating hormone plays a huge role in weight regulation
It helps maintain the balance between energy from food taken into the body and energy spent by the body
It’s also anti-inflammatory
Beta-melanocyte stimulating hormone plays a huge role in weight regulation
It helps maintain the balance between energy from food taken into the body and energy spent by the body
It’s also anti-inflammatory
4. Îł-MSH
Gamma-melanocyte stimulating hormone seems to regulate sodium in the body and controls blood pressure
Appetite regulation, thermoregulation, anti-inflammatory, neuroprotective
Laundry list of benefits
Gamma-melanocyte stimulating hormone seems to regulate sodium in the body and controls blood pressure
Appetite regulation, thermoregulation, anti-inflammatory, neuroprotective
Laundry list of benefits
5. ACTH
Adrenocorticotropic hormone stimulates the release of cortisol
This hormone helps maintain blood sugar (glucose) levels, protects the body from stress, and stops inflammation
Keep this in mind as we discuss toxic artificial light and diabetes
Adrenocorticotropic hormone stimulates the release of cortisol
This hormone helps maintain blood sugar (glucose) levels, protects the body from stress, and stops inflammation
Keep this in mind as we discuss toxic artificial light and diabetes
6. CLIP
Corticotropin-like intermediate peptide is an insulin secretagog
In other words, it stimulates the secretion of insulin from the pancreas
Also important to keep in mind along with ACTH for metabolic syndrome
Corticotropin-like intermediate peptide is an insulin secretagog
In other words, it stimulates the secretion of insulin from the pancreas
Also important to keep in mind along with ACTH for metabolic syndrome
7. β-endorphin
Beta endorphin is an opioid peptide one I’ve covered before
It’s largely responsible for why we’re biologically driven to be addicted to sunlight
Beta endorphin is an opioid peptide one I’ve covered before
It’s largely responsible for why we’re biologically driven to be addicted to sunlight
8. [Met]Enkephalin
Metenkefalin is another opioid peptide known as opioid growth factor (OGF)
It largely serves the same function as beta-endorphin for pain, mood enhancement, mental health
It’s also a cell growth inhibitor, making it a potential cancer treatment
Metenkefalin is another opioid peptide known as opioid growth factor (OGF)
It largely serves the same function as beta-endorphin for pain, mood enhancement, mental health
It’s also a cell growth inhibitor, making it a potential cancer treatment
9. β-Lipotropin & γ-LPH
A peptide hormone produced by the anterior pituitary gland
It’s a precursor to several other hormones, including beta-endorphin
Gamma lipotropin (Îł-LPH) can influence the breakdown of fat in the body
A peptide hormone produced by the anterior pituitary gland
It’s a precursor to several other hormones, including beta-endorphin
Gamma lipotropin (Îł-LPH) can influence the breakdown of fat in the body
Notice the overlap in every single one of these peptides that are cleaved from POMC
Full body regulation of metabolism
This is powerful stuff
And you can use this information to your biological advantage for health
Full body regulation of metabolism
This is powerful stuff
And you can use this information to your biological advantage for health
Just to illustrate a stark example (there are many of them)
Our biology evolved with sunlight, the full light spectrum, to make the most of POMC
So what impact does artificial light have on this gene and its peptide derivatives?
A nasty one
Our biology evolved with sunlight, the full light spectrum, to make the most of POMC
So what impact does artificial light have on this gene and its peptide derivatives?
A nasty one
Isolated blue light hijacks POMC, ACTH, and CLIP to raise insulin and blood sugar, independent of what you eat
Millions are setting themselves up for insulin resistance and diabetes because of the light around them
That sounds insane to most
Millions are setting themselves up for insulin resistance and diabetes because of the light around them
That sounds insane to most
But it’s not when you understand that all chronic disease stems from insulin resistance
Obesity, diabetes, heart disease, cancer, all convert at this intersection of biology
Food quality is important
But it takes a backseat to light
Obesity, diabetes, heart disease, cancer, all convert at this intersection of biology
Food quality is important
But it takes a backseat to light
If you deny this, you’re denying billions of years of evolutionary and quantum biology
Think twice about what light you’re bathed in all day
This is the foundation of health
Health or disease is largely determined by the quality of your light environment
Think twice about what light you’re bathed in all day
This is the foundation of health
Health or disease is largely determined by the quality of your light environment
Want practical takeaways?
Get AM sunlight
Build a solar callus through progressive overload of sun exposure, regardless of skin type
Sunbathe routinely
Build your melanin
Watch sunrise and sunset
Toss the sunglasses and sunscreen
Block artificial light religiously below
Get AM sunlight
Build a solar callus through progressive overload of sun exposure, regardless of skin type
Sunbathe routinely
Build your melanin
Watch sunrise and sunset
Toss the sunglasses and sunscreen
Block artificial light religiously below
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