Health Alternative Medicine Nutrition Antioxidant AntiCancer/Tumor
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@MindOfIntra

12 Tweets 6 reads Mar 20, 2024
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Black Seed Oil has a long history of use, and for good reason
Derived from the seeds of the Nigella sativa, BSO Oil is known for its diverse therapeutic properties:
-Antioxidant
-Anti-Cancer/Tumor
-Cholesterol Lowering Effects
and much more
Let's start with it's constituents⬇️
Thymoquinone:
A potent antioxidant, anti-inflammatory, and anti-cancer compound that has been shown to inhibit cancer-cell proliferation, induce apoptosis, and suppress tumor growth in various types of cancerous tumors via inhibition of NF-κB/STAT3 and modulation of MAPK.
Thymohydroquinone:
Relatively similar to thymoquinone via antioxidant effects, protecting cells from oxidative damage, etc.
The difference? Alternative MoA's for anti-inflammation via inhibition pro-inflammatory cytokines and enzymes (COX-2 and iNOS)
Dithymoquinone:
-Inhbits NF-κB & STAT3
-Inhibits the proliferation/metastasis of cancer cells via modulation of cell cycle progression and epithelial-mesenchymal transition
-Reduces release of Inflammatory Cytokines
-Enhances the activity of superoxide dismutase & catalase
Nigellone:
-Modulates immune responses via regulation of immune cells
-Enhances the production of anti-inflammatory cytokines while suppressing secretion of pro-inflammatory cytokines (f.ex: IL-1β, IL-6, and TNF-α)
Beta-Sitosterol:
-Lowers LDL-C, via NPC1L1 inhibition
-Suppresses migration/activation of immune cells involved in inflammation (macrophages & T lymphocytes)
-Enhances proliferation & activity of Cytotoxic T Lymphocytes & NKC's
-Enhances production of Interferons/Interleukins
Some trace compounds:
-Carvacrol, an Antimicrobial/fungal/parasitic
-Triterpenes: Decreases P-IC release
-Myristic Acid: Decreases neuroinflammation, modulates lipid metabolism, improves cellular signaling
Myristic Acid:
Undergoes Myristoylation (covalent attachment of myristic acid to N-terminal glycine residue of proteins) anchoring them to cell membranes & facilitating interaction with intracellular signaling molecules, improves insulin sensitivity/glucose metabolism, etc.
Carvacrol:
-Free Radical Scavenging (ROS mainly)
-Antimicrobial (disrupts microbial cell membranes, inhibiting pathogens)
-Enhances endogenous Antioxidants (also SOD & Catalase)
-Inhibits tumor Angiogenesis
-Cancer Cell Proliferation inhibition via PI3K/AKT & MAPK interference
BSO is a powerhouse.
-Anti: Inflammation, Neurodegeneration, Cancer, Tumor, Fungal, Microbial, etc
-Helps Lower LDL-C
-Free Radical Scavenger
-Antioxidant Properties
-Immune Function
-Promotes Wound Healing & Tissue Growth
-Reduce Swelling
Definitely a staple for your stack.
Can also help spermatogenesis, sperm motility and volume in men as well according to some studies 👀
I prefer the @Merakimedicinal BSO as of right now, but I also use the Nootropics Depot 10% Thymoquinone capsules.
I love both.
@Merakimedicinal [1] pubmed.ncbi.nlm.nih.gov
[2] pubmed.ncbi.nlm.nih.gov
[3] pubmed.ncbi.nlm.nih.gov
[4] pubmed.ncbi.nlm.nih.gov
[5] pubmed.ncbi.nlm.nih.gov
[6] pubmed.ncbi.nlm.nih.gov
[7] pubmed.ncbi.nlm.nih.gov
pubmed.ncbi.nlm.nih.gov/24680621/

Effects of Nigella sativa L. seed oil on abnormal semen quality in infertile men: a randomized, double-blind, placebo-controlled clinical trial - PubMed

In recent years, wide utilization of herbal drugs has encouraged scientists to determine their impre...
A crossover randomized controlled trial examining the effects of black seed (Nigella sativa) supplementation on IL-1β, IL-6 and leptin, and insulin parameters in overweight and obese women - PubMed
pubmed.ncbi.nlm.nih.gov/38178093/

A crossover randomized controlled trial examining the effects of black seed (Nigella sativa) supplementation on IL-1β, IL-6 and leptin, and insulin parameters in overweight and obese women - PubMed

IRCT20180430039475N1 (Date:25/6/2018).
pubmed.ncbi.nlm.nih.gov/34407441/

Nigella sativa for the treatment of COVID-19: An open-label randomized controlled clinical trial - PubMed

NSO supplementation was associated with faster recovery of symptoms than usual care alone for patien...
Efficacy of nigella sativa oil on endothelial function and atherogenic indices in patients with coronary artery diseases: A randomized, double-blind, placebo-control clinical trial - PubMed
pubmed.ncbi.nlm.nih.gov/35871718/

Efficacy of nigella sativa oil on endothelial function and atherogenic indices in patients with coronary artery diseases: A randomized, double-blind, placebo-control clinical trial - PubMed

A therapeutic compound with antioxidant and anti-inflammatory effects might be a practical approach...
Effect of Nigella Sativa oil versus metformin on glycemic control and biochemical parameters of newly diagnosed type 2 diabetes mellitus patients - PubMed
pubmed.ncbi.nlm.nih.gov/31152309/

Effect of Nigella Sativa oil versus metformin on glycemic control and biochemical parameters of newly diagnosed type 2 diabetes mellitus patients - PubMed

NS administration in newly diagnosed T2DM was tolerable with no side effects as compared to metformi...
Nigella sativa oil with a calorie-restricted diet can improve biomarkers of systemic inflammation in obese women: A randomized double-blind, placebo-controlled clinical trial - PubMed
pubmed.ncbi.nlm.nih.gov/27678438/

Nigella sativa oil with a calorie-restricted diet can improve biomarkers of systemic inflammation in obese women: A randomized double-blind, placebo-controlled clinical trial - PubMed

NS oil supplementation combined with a calorie-restricted diet may modulate systemic inflammatory bi...
pubmed.ncbi.nlm.nih.gov/28093815/

Nigella sativa Supplementation Improves Asthma Control and Biomarkers: A Randomized, Double-Blind, Placebo-Controlled Trial - PubMed

Poor compliance with conventional asthma medications remains a major problem in achieving asthma con...

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Health Alternative Medicine Nutrition Antioxidant AntiCancer/Tumor

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